Epigenetic Regulation of Enteric Neurotransmission by Gut Bacteria

Frontiers in Cellular Neuroscience
Tor C Savidge

Abstract

The Human Microbiome Project defined microbial community interactions with the human host, and provided important molecular insight into how epigenetic factors can influence intestinal ecosystems. Given physiological context, changes in gut microbial community structure are increasingly found to associate with alterations in enteric neurotransmission and disease. At present, it is not known whether shifts in microbial community dynamics represent cause or consequence of disease pathogenesis. The discovery of bacterial-derived neurotransmitters suggests further studies are needed to establish their role in enteric neuropathy. This mini-review highlights recent advances in bacterial communications to the autonomic nervous system and discusses emerging epigenetic data showing that diet, probiotic and antibiotic use may regulate enteric neurotransmission through modulation of microbial communities. A particular emphasis is placed on bacterial metabolite regulation of enteric nervous system function in the intestine.

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Feb 7, 2017·Gastroenterology Clinics of North America·Eamonn M M Quigley
Oct 19, 2017·Current Neurology and Neuroscience Reports·Eamonn M M Quigley
Jun 22, 2018·Biological Research for Nursing·Michelle L WrightVicki Stover Hertzberg
Apr 2, 2019·Frontiers in Microbiology·Gregor ReidRaja Dhir
Jun 8, 2021·Frontiers in Endocrinology·Sik Yu So, Tor C Savidge

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Methods Mentioned

BETA
nucleic acid amplification
transgenic

Software Mentioned

Jumpstart

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