Epigenetic regulation of gene expression and M2 macrophage polarization as new potential omega-3 polyunsaturated fatty acid targets in colon inflammation and cancer

Expert Opinion on Therapeutic Targets
Simona SeriniGabriella Calviello

Abstract

It has become increasingly clear that dietary habits may affect the risk/progression of chronic diseases with a pathogenic inflammatory component, such as colorectal cancer. Considerable attention has been directed toward the ability of nutritional agents to target key molecular pathways involved in these inflammatory-related diseases. ω-3 Polyunsaturated fatty acids (PUFA) and their oxidative metabolites have attracted considerable interest as possible anti-inflammatory and anti-cancer agents, especially in areas such as the large bowel, where the influence of orally introduced substances is high and tumors show deranged PUFA patterns. On this basis, we have analyzed pre-clinical findings that have recently revealed new insight into the molecular pathways targeted by ω-3 PUFA. The findings analyzed herein demonstrate that ω-3 PUFA may exert beneficial effects by targeting the epigenetic regulation of gene expression and altering M2 macrophage polarization during the inflammatory response. These mechanisms need to be better explored in the large bowel, and further studies could better clarify their role and the potential of dietary interventions with ω-3 PUFA in the large bowel. The epigenomic mechanism is discussed in view of ...Continue Reading

References

Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·B D StrahlC D Allis
Apr 20, 2000·The Journal of Biological Chemistry·D A Brown, E London
Nov 25, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Z Y Chen, N W Istfan
Jun 11, 2003·Progress in Experimental Tumor Research·John A Baron
Oct 29, 2003·Chemistry and Physics of Lipids·William Stillwell, Stephen R Wassall
Dec 9, 2003·Mechanisms of Ageing and Development·Liang LiuTrygve O Tollefsbol
Jan 10, 2004·Advances in Experimental Medicine and Biology·Wim Vanden BergheGuy Haegeman
Mar 9, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wanchao MaAbraham Spector
Sep 15, 2004·Cancer Chemotherapy and Pharmacology·Gabriella CalvielloPaola Palozza
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang-Yi FanRobert S Chapkin
Nov 18, 2004·The Journal of Pharmacology and Experimental Therapeutics·Regine Schneider-StockHala Gali-Muhtasib
Dec 14, 2004·The Journal of Nutritional Biochemistry·David W L MaRobert S Chapkin
Dec 28, 2004·Nature Medicine·Akira HirasawaGozoh Tsujimoto
Feb 28, 2006·Molecular Immunology·Gopal GopisettyRakesh Singal
Aug 22, 2006·International Journal of Cancer. Journal International Du Cancer·G FürstenbergerA J R Habenicht
Sep 1, 2006·The New England Journal of Medicine·Monica M BertagnolliUNKNOWN APC Study Investigators
Sep 1, 2006·The New England Journal of Medicine·Nadir ArberUNKNOWN PreSAP Trial Investigators
Feb 27, 2007·Cell·Tony Kouzarides
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Pierre J Issa
Apr 7, 2007·Pediatric Research·Jody C Chuang, Peter A Jones
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Yves M DupertuisClaude Pichard
Aug 25, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satya Sree N KolarRobert S Chapkin
Mar 18, 2008·Chemistry and Physics of Lipids·Rafat A SiddiquiWilliam Stillwell
Jul 8, 2008·The Journal of Nutritional Biochemistry·Patricia D BiondoCatherine J Field
Oct 1, 2008·Seminars in Arthritis and Rheumatism·Harald E Vonkeman, Mart A F J van de Laar
Dec 5, 2008·Molecular & Cellular Proteomics : MCP·Simona G CodreanuDaniel C Liebler
Dec 24, 2008·The Journal of Experimental Medicine·Charles N SerhanMatthew Spite

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Citations

Jul 10, 2018·Carcinogenesis·Chiara PortaAntonio Sica
Dec 13, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Simona Serini, Gabriella Calviello
Nov 5, 2016·Nutrition and Metabolic Insights·Salma A AbdelmagidDavid W L Ma
Sep 16, 2020·Nutrients·Stefania D'AngeloRosaria Meccariello
Dec 13, 2017·International Journal of Molecular Sciences·Simona SeriniGabriella Calviello
Jan 9, 2020·World Journal of Clinical Cases·Mostafa Moradi SarabiEbrahim Eftekhar
Jun 13, 2020·International Journal of Molecular Sciences·Bianka BojkováMagdalena Wszedybyl-Winklewska
Dec 2, 2020·Basic & Clinical Pharmacology & Toxicology·Shasha HouXiaxia Yuan
Nov 16, 2021·Lipids in Health and Disease·Do-Won JeongYang-Sook Chun

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