Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin.

The Journal of Nutritional Biochemistry
Jung-Mi YunSridevi Devaraj

Abstract

Diabetes is a proinflammatory state. We have previously shown increased monocyte proinflammatory cytokines in patients with Type 1 and Type 2 diabetes. High glucose induces proinflammatory cytokines via epigenetic changes. Curcumin, a polyphenol responsible for the yellow color of the spice turmeric, is known to exert potent anti-inflammatory activity in vitro. Recent studies indicate that it may regulate chromatin remodeling by inhibiting histone acetylation. In this study, we aimed to test the effect of curcumin on histone acetylation and proinflammatory cytokine secretion under high-glucose conditions in human monocytes. Human monocytic (THP-1) cells were cultured in presence of mannitol (osmolar control, mannitol) or normoglycemic (NG, 5.5 mmol/L glucose) or hyperglycemic (HG, 25 mmol/L glucose) conditions in absence or presence of curcumin (1.5-12.5 μM) for 72 h. Cytokine level, nuclear factor κB (NF-κB) transactivation, histone deacetylases (HDACs) activity, histone acetylases (HATs) activity were measured by western blots, quantitative reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, immunofluorescence staining. HG significantly induced histone acetylation, NF-κB activity and proinflamm...Continue Reading

References

Mar 1, 1991·Diabetes/metabolism Reviews·G PuglieseJ R Williamson
Feb 25, 1993·The American Journal of Cardiology·T J Lyons
Jan 23, 1999·The Journal of Clinical Investigation·M IgarashiG L King
May 10, 2000·Current Opinion in Cell Biology·W L CheungC D Allis
Jun 23, 2001·Oncogene·A P Wolffe
Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·O H KrämerT Heinzel
Mar 15, 2002·Current Opinion in Genetics & Development·Shelley L Berger
Mar 21, 2002·Nature Reviews. Cancer·P MarksW K Kelly
Apr 3, 2003·Nature Reviews. Molecular Cell Biology·Siavash K Kurdistani, Michael Grunstein
Jul 3, 2003·The Journal of Biological Chemistry·Narkunaraja ShanmugamRama Natarajan
Dec 6, 2003·The EMBO Journal·Caroline RouauxAnne-Laurence Boutillier
Feb 21, 2004·The Journal of Biological Chemistry·Feng MiaoRama Natarajan
Mar 9, 2004·Nature Structural & Molecular Biology·Paul R ThompsonPhilip A Cole
Mar 26, 2004·Trends in Genetics : TIG·Timothy A McKinsey, Eric N Olson
Jul 7, 2005·Antioxidants & Redox Signaling·Joseph L EvansIra D Goldfine
Jul 14, 2005·Annual Review of Nutrition·U SinghI Jialal
Jun 22, 2006·Medicinal Chemistry·Monica G MarcuLen Neckers
Aug 22, 2006·Biochemical Pharmacology·Irfan RahmanPaul A Kirkham
Feb 20, 2007·The American Journal of Cardiology·Paresh DandonaPriya Mohanty
May 19, 2007·Antioxidants & Redox Signaling·Mark R NicollsSonia C Flores
May 19, 2007·Antioxidants & Redox Signaling·Subramaniam Pennathur, Jay W Heinecke
Aug 22, 2007·Trends in Cell Biology·J Lyon, N B La Thangue
Oct 2, 2007·Journal of the American College of Nutrition·Swen Wolfram
Feb 13, 2008·Cell·Matthew S Hayden, Sankar Ghosh
Feb 24, 2009·International Journal of Cardiology·Wanwarang Wongcharoen, Arintaya Phrommintikul

❮ Previous
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Citations

Apr 26, 2011·Genes & Nutrition·Simone ReuterBharat B Aggarwal
Feb 22, 2012·Journal of Physiology and Biochemistry·M I Maldonado-CervantesF Martinez-Morales
Mar 7, 2012·The Proceedings of the Nutrition Society·J Alfredo MartínezFermín I Milagro
Jan 27, 2011·Cardiovascular Research·Marpadga A Reddy, Rama Natarajan
Jun 7, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Elaine M Drummond, Eileen R Gibney
Feb 12, 2011·Clinical and Experimental Pharmacology & Physiology·Louisa M VilleneuveRama Natarajan
Jul 3, 2013·Nutrients·Alejandro CuevasDulcineia S P Abdalla
Feb 18, 2012·Future Oncology·Adeeb ShehzadYoung Sup Lee
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Wei ZhangJun-Li Liu
Jul 9, 2014·Nature Reviews. Nephrology·Mitsuo Kato, Rama Natarajan
Jan 16, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hye Joo KimJung-Mi Yun
Sep 10, 2013·Seminars in Nephrology·Marpadga A ReddyRama Natarajan
Sep 18, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Thomas BuchheitAndrew Shaw
Jun 12, 2013·Molecular Nutrition & Food Research·Marie-Hélène TeitenMarc Diederich
Jul 10, 2012·Molecular Aspects of Medicine·F I MilagroJ A Martínez
Dec 3, 2014·Archives of Oral Biology·Xiaodong ZhouYiming Li
May 13, 2014·European Journal of Nutrition·Lucia LaubertováIngrid Zitňanová
May 1, 2016·Neuroscience Letters·Rami Al-HaddadSama F Sleiman
Jul 6, 2016·Journal of Diabetes Research·Xiaoxia LiGuangdong Sun
Jan 7, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Linda SommeseClaudio Napoli
Jan 7, 2017·Journal of Cellular Physiology·Elham AbdollahiAmirhossein Sahebkar
May 10, 2017·Journal of Cellular Biochemistry·Jafar HajaviAmirhossein Sahebkar
Nov 17, 2015·Nutrients·Charlotte GrootaertJohn Van Camp
Feb 14, 2013·Synapse·Kaneez Fatima ShadBodo Kress
Sep 27, 2018·International Journal of Environmental Research and Public Health·Yoona Kim, Peter Clifton
Nov 30, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Mahsa HatamiNiyaz Mohammadzadeh Honarvar
Jan 12, 2017·Reviews on Environmental Health·Jessie B HoffmanBernhard Hennig
Dec 26, 2015·European Journal of Nutrition·Isabel Cordero-HerreraSridevi Devaraj
Mar 24, 2018·International Journal of Inflammation·Franco Cavaleri
Jun 5, 2018·BioMed Research International·Weilei YaoFeiruo Huang

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