Epigenetic regulation of matrix metalloproteinases in inflammatory diseases: a narrative review

Cell & Bioscience
Jie HeTianqian Hui

Abstract

With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the metabolism of extracellular matrix (ECM). They play a key role in inflammation-related diseases. Factors such as inflammation, oxidative stress and growth factors stimulate the production of MMPs with subsequent ECM remodeling. Recently, the studies of epigenetic regulation, including the ability to predict disease progression, important pathophysiological deficiencies as well as treatment methods have been extensively discussed. This article reviews the current studies on epigenetic alterations in MMPs during inflammatory response. It is likely to provide new insights into development of efficient medications of epigenetic therapy for inflammatory diseases.

References

Dec 2, 2000·Nature·M VogelauerM Grunstein
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·S TimmermannA Harel-Bellan
Nov 14, 2002·The Biochemical Journal·Annemieke J M de RuijterAndré B P van Kuilenburg
Feb 19, 2004·Advances in Protein Chemistry·Adam Wood, Ali Shilatifard
Aug 18, 2004·Genome Research·Naka HattoriKunio Shiota
Sep 17, 2004·Nature·Victor Ambros
Mar 31, 2005·Molecular and Cellular Biology·Xiang-Jiao Yang, Serge Grégoire
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
May 3, 2006·Human Molecular Genetics·John S Mattick, Igor V Makunin
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Feb 27, 2007·Cell·Tony Kouzarides
Mar 1, 2007·Arthritis and Rheumatism·Peter S BurrageConstance E Brinckerhoff
Mar 14, 2007·Acta Odontologica Scandinavica·Angélica R HannasLeo Tjäderhane
Aug 22, 2007·Journal of Cellular Physiology·Tina Branscombe Miranda, Peter A Jones
Feb 9, 2008·The International Journal of Biochemistry & Cell Biology·Ian M ClarkDylan R Edwards
Apr 3, 2008·Arthritis and Rheumatism·Joanna StanczykDiego Kyburz
Nov 6, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marco A da SilvaHelmtrud I Roach
Mar 31, 2009·Pulmonary Pharmacology & Therapeutics·Nancy GarbackiAlain Colige
Apr 1, 2009·Arthritis and Rheumatism·Keiichiro YamasakiMitsuo Ochi
Apr 3, 2009·Genes & Development·Shelley L BergerAli Shilatifard
Dec 2, 2009·BMC Musculoskeletal Disorders·Ginette TardifJohanne Martel-Pelletier
Dec 2, 2009·Arthritis and Rheumatism·Emmanuel KarouzakisMichel Neidhart
Mar 3, 2010·Immunological Reviews·Beatrix Bartok, Gary S Firestein
Mar 23, 2010·Cell·Carl Nathan, Aihao Ding
Nov 16, 2010·FEBS Letters·Alessandra Di Lorenzo, Mark T Bedford
Apr 15, 2011·The Journal of Clinical Investigation·Eveline J SteineHeinz G Linhart
Nov 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucas PhilippeSébastien Pfeffer
Dec 22, 2011·International Journal of Epidemiology·C H Waddington
Apr 5, 2012·Nature Reviews. Genetics·Eric L Greer, Yang Shi
Apr 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine BuiDavid A Young
May 29, 2012·Current Pharmaceutical Design·D B Vendramini-Costa, J E Carvalho
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·Marilyne Labrie, Yves St-Pierre
Apr 30, 2013·Cell·Luke A YatesRobert J C Gilbert

❮ Previous
Next ❯

Citations

Jan 10, 2021·International Journal of Molecular Sciences·Griselda A Cabral-PachecoMargarita L Martinez-Fierro

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
acetylation
histone acetylation

Related Concepts

Related Feeds

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Related Papers

Frontiers in Bioscience (Landmark Edition)
Matthew AminUtpal Sen
International Journal of Molecular Sciences
Griselda A Cabral-PachecoMargarita L Martinez-Fierro
Journal of Molecular and Cellular Cardiology
Vincent Lagente, Elisabeth Boichot
© 2021 Meta ULC. All rights reserved