Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies

Neuroscience Letters
Matthew DevallKatie Lunnon

Abstract

The field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis. However, current publications have been limited by the use of global or targeted methods of measuring DNA methylation. In this review, we discuss current findings in mitochondrial epigenetics as well as its potential role as a regulator of mitochondria within the brain. Finally, we summarize the current technologies best suited to capturing mtDNA methylation, and how a move towards whole epigenome sequencing of mtDNA may help to advance our current understanding of the field.

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Citations

Jun 12, 2016·Neuroscience Letters·John W CaveRajiv R Ratan
May 6, 2017·Clinical Epigenetics·Matthew DevallKatie Lunnon
Jul 4, 2017·Clinical Epigenetics·Raúl Delgado-MoralesMaría Berdasco
Mar 7, 2019·Frontiers in Endocrinology·Fabio Coppedè, Andrea Stoccoro
Jun 28, 2019·Frontiers in Cellular Neuroscience·James P HighamJames J L Hodge
May 1, 2021·International Journal of Molecular Sciences·Andrea Stoccoro, Fabio Coppedè

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