Epigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemia

Leukemia Research
Sampa Ghoshal GuptaM Wetzler

Abstract

We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic protein tyrosine kinases or from autocrine stimulation by hematopoietic growth factors. These causes are generally neither necessary nor sufficient for leukemogenesis; additional transforming events or growth stimulatory processes are needed. Here we review the literature addressing epigenetic regulation as a mechanism controlling STAT3 signaling in AML. A better understanding of mechanisms of dysregulation of STAT signaling pathways may serve as a basis for designing novel therapeutic strategies that target these pathways in leukemia cells.

References

Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Antequera, A Bird
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Daiya Takai, Peter A Jones
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael A Rycyzyn, Charles V Clevenger
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lewis R SilvermanJames F Holland
Jun 4, 2002·Current Opinion in Hematology·D Gary Gilliland, James D Griffin
Dec 14, 2002·Blood·Mustafa BenekliMeir Wetzler
Dec 20, 2002·Blood Reviews·Derek L StirewaltJerald P Radich
May 22, 2003·Genes, Chromosomes & Cancer·Chien-Yuan ChenHwei-Fang Tien
Oct 9, 2003·British Journal of Haematology·Masuzu UedaHiroyuki Mano
Nov 11, 2003·The Journal of Biological Chemistry·Samuel Wormald, Douglas J Hilton
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Biao HeDavid M Jablons
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frédéric BlanchardHeinz Baumann
Mar 10, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony T C ChanRichard F Ambinder
Apr 13, 2004·Journal of Gastroenterology·Shinichi FujitakeAkimasa Nakao
May 4, 2004·Japanese Journal of Clinical Oncology·Toshiaki KomazakiTadamitsu Kishimoto
Aug 26, 2004·British Journal of Haematology·Dai WatanabeTadamitsu Kishimoto
Sep 8, 2004·Gynecologic Oncology·Huaizeng ChenWeiguo Lu
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Yasuhiro OshimoWataru Yasui
Mar 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfram E SamlowskiAdam R Karpf
Mar 31, 2005·Current Opinion in Genetics & Development·Michael Freitag, Eric U Selker
May 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qian ZhangMariusz A Wasik
May 11, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre J IssaHagop M Kantarjian
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edvardas KaminskasUNKNOWN FDA
Jun 7, 2005·Biochemical Pharmacology·Kriti Rakesh, Devendra K Agrawal
Jun 21, 2005·Immunity·Takashi TanakaMichael J Grusby

❮ Previous
Next ❯

Citations

Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mustafa BenekliMeir Wetzler
Nov 7, 2014·Expert Review of Hematology·Øystein BruserudHåkon Reikvam
Jul 21, 2010·Genes, Chromosomes & Cancer·Ruth N MackinnonLynda J Campbell
May 12, 2012·Arthritis and Rheumatism·Fons A J van de LooWim B van den Berg
Jul 2, 2016·Blood Cancer Journal·I De Kouchkovsky, M Abdul-Hay
Aug 29, 2020·European Journal of Medicinal Chemistry·Beichen HuLixia Chen
Aug 28, 2021·Biomedicines·Bernhard MoserDagmar Stoiber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.