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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

Nature Neuroscience

Mar 1, 2009

Patrick O McGowanMichael Joseph Meaney

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Abstract

Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stress responses and increases the risk of suicide. We examined epigenetic differences in a neuro...read more

Mentioned in this Paper

Pituitary Hormone Suppressant
EGR1 gene
Study of Epigenetics
Transcription Factor Binding
NR3C1 protein, human
Adult Survivors of Child Abuse
Early Promoters, Genetic
NR3C1 gene
Suicide
NR3C1 wt Allele
19
6
8
1914
1
5
Paper Details
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

Nature Neuroscience

Mar 1, 2009

Patrick O McGowanMichael Joseph Meaney

PMID: 19234457

DOI: 10.1038/nn.2270

Abstract

Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stress responses and increases the risk of suicide. We examined epigenetic differences in a neuro...read more

Mentioned in this Paper

Pituitary Hormone Suppressant
EGR1 gene
Study of Epigenetics
Transcription Factor Binding
NR3C1 protein, human
19
6
8
1914
1
5

Related Papers

Paper Details
References
  • References48
  • Citations1031
12345
  • References48
  • Citations1031
12345...

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