Jan 11, 2011

Epigenetic regulation of transposable element derived human gene promoters

Gene
Ahsan HudaI King Jordan

Abstract

It was previously thought that epigenetic histone modifications of mammalian transposable elements (TEs) serve primarily to defend the genome against deleterious effects associated with their activity. However, we recently showed that, genome-wide, human TEs can also be epigenetically modified in a manner consistent with their ability to regulate host genes. Here, we explore the ability of TE sequences to epigenetically regulate individual human genes by focusing on the histone modifications of promoter sequences derived from TEs. We found 1520 human genes that initiate transcription from within TE-derived promoter sequences. We evaluated the distributions of eight histone modifications across these TE-promoters, within and between the GM12878 and K562 cell lines, and related their modification status with the cell-type specific expression patterns of the genes that they regulate. TE-derived promoters are significantly enriched for active histone modifications, and depleted for repressive modifications, relative to the genomic background. Active histone modifications of TE-promoters peak at transcription start sites and are positively correlated with increasing expression within cell lines. Furthermore, differential modificatio...Continue Reading

  • References50
  • Citations20

References

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Genome-Wide Association Study
Histone antigen
Exons
Genome
Transcription Initiation Site
E.N.T.
Ncbi Taxonomy
Tissue-Specific Gene Expression
Transcription Initiation

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