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Epigenetic reprogramming in mammalian development

Science

Aug 10, 2001

Wolf ReikJames D C Walter

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Abstract

DNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are at least two developmental periods-in germ cell...read more

Mentioned in this Paper

Congenital Abnormality
Cell Differentiation Process
Clone Cells
Cloning
Dinucleoside Phosphates
Embryo
Enzymology
Gene Expression
Genome
Germ Cells
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2
1248
4
Paper Details
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Epigenetic reprogramming in mammalian development

Science

Aug 10, 2001

Wolf ReikJames D C Walter

PMID: 11498579

DOI: 10.1126/science.1063443

Abstract

DNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are at least two developmental periods-in germ cell...read more

Mentioned in this Paper

Congenital Abnormality
Cell Differentiation Process
Clone Cells
Cloning
Dinucleoside Phosphates
7
2
1248
4
Paper Details
References
  • References
  • Citations1289
  • References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations1289
12345...

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