Feb 28, 2020

Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases

Pharmacology & Therapeutics
Concetta SchianoClaudio Napoli

Abstract

The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be explained. Aberrant epigenetic changes may result from alterations in enzymatic activities, which are responsible for putting in and/or out the covalent groups, altering the epigenome and then modulating gene expression. The identification of novel individual epigenetic-sensitive trajectories at single cell level might provide additional opportunities to establish predictive, diagnostic and prognostic biomarkers as well as drug targets in CVDs. To date, most of studies investigated DNA methylation mechanism and miRNA regulation as epigenetics marks. During atherogenesis, big epigenetic changes in DNA methylation and different ncRNAs, such as miR-93, miR-340, miR-433, miR-765, CHROME, were identified into endothelial cells, smooth muscle cells, and macrophages. During man development, lipid metabolism, inflammation and homocysteine homeostasis, alter vascular transcriptional mechanism of fundamental genes such as ABCA1, SREBP2, NOS, HIF1. At histone level, increased HDAC9 was associated with matrix metalloproteinase 1 (MMP1) and MMP2 expression in pro-inflammatory macrophages of human carotid plaque other than to have a positive effect on toll like ...Continue Reading

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Mentioned in this Paper

HIF1A gene
Peripheral Arterial Diseases
Sterol Regulatory Element Binding Protein 2
Male Population Group
Transcription, Genetic
Receptor Signaling
MIR433 gene
Atherosclerosis
Inflammation
Physiologic Resolution

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