Epigenetic signature: implications for mitochondrial quality control in human aging

Aging
Patrizia D'AquilaDina Bellizzi

Abstract

Maintenance of functional mitochondria is essential to prevent damage leading to aging and diseases. What is more, the research of biomarkers of aging is focusing on better predicting functional capability along the lifetime beyond chronological age. Aim of this study was to identify novel CpG sites the methylation of which might be correlated to the chronological and biological age. We performed methylation analyses of the CpG sites in candidate genes involved in mitochondrial biogenesis, mitophagy, fusion, and fission, all key quality control mechanisms to ensure maintenance of healthy mitochondria and homeostasis during aging, using DNA samples from two independent datasets composed by 381 and 468 differently-aged individuals, respectively. Twelve potential CpG predictors resulted associated with aging in the discovery dataset. Of these, two sites located within RAB32 and RHOT2 genes were replicated in the second dataset. What is more, individuals exhibiting methylation levels of the RAB32 CpG site higher than 10% were observed more prone to disability than people with lower levels.These results seem to provide the first evidence that epigenetic modifications of genes involved in mitochondrial quality control occur over time...Continue Reading

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Citations

Nov 14, 2019·Current Pharmaceutical Design·Francesco GuarasciGiuseppe Passarino
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May 16, 2020·Journal of Clinical Medicine·Anna PiccaEmanuele Marzetti
Aug 19, 2020·Antioxidants & Redox Signaling·Stefano MasiSarah Costantino

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Methods Mentioned

BETA
protein folding
methylation profiling
PCR
GTPase
PCRs
in vitro transcription
chips

Software Mentioned

Sequenom
EpiDesigner
CpGassoc
ggplot2
bootStepAIC
EPITYPER
R

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