Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection

Proceedings of the National Academy of Sciences of the United States of America
Abhik SahaErle S Robertson

Abstract

DNA-methylation at CpG islands is one of the prevalent epigenetic alterations regulating gene-expression patterns in mammalian cells. Hypo- or hypermethylation-mediated oncogene activation, or tumor suppressor gene (TSG) silencing mechanisms, widely contribute to the development of multiple human cancers. Furthermore, oncogenic viruses, including Epstein-Barr virus (EBV)-associated human cancers, were also shown to be influenced by epigenetic modifications on the viral and cellular genomes in the infected cells. We investigated EBV infection of resting B lymphocytes, which leads to continuously proliferating lymphoblastoid cell lines through examination of the expression pattern of a comprehensive panel of TSGs and the epigenetic modifications, particularly methylation of their regulatory sequences. EBV infection of primary B lymphocytes resulted in global transcriptional repression of TSGs through engagement of hypermethylation. Therefore, CpG methylation profiles of TSGs may be used as a prognostic marker as well as development of potential therapeutic strategies for controlling acute infection and EBV-associated B-cell lymphomas.

References

Jun 23, 2001·Oncogene·K D Robertson
Jul 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chi-Neu TsaiYu-Sun Chang
May 20, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S W TsaoY C Wong
Nov 5, 2003·Medical and Pediatric Oncology·Bruce Shiramizu, Paul Mick
Jan 30, 2004·Journal of Virology·Wen-hai FengShannon C Kenney
Feb 7, 2006·Trends in Microbiology·Paul M Lieberman
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Meir ShamayS Diane Hayward
Sep 20, 2006·Oncogene·W A BurgersF Fuks
Jan 19, 2008·Biochimica Et Biophysica Acta·Margaret E McLaughlin-Drubin, Karl Munger
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller
Jun 1, 2007·Molecular Oncology·Santiago Ropero, Manel Esteller
May 12, 2009·Seminars in Cancer Biology·Hans Helmut NillerJanos Minarovits
Nov 3, 2010·Oncology Reports·Chi Lam Au YeungTim Tak Kwok
Nov 19, 2010·Cancer Biology & Therapy·Abhik SahaErle S Robertson
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Seiji MaruoKenzo Takada
Mar 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Abhik Saha, Erle S Robertson
Sep 24, 2011·Genes & Cancer·Bilian JinKeith D Robertson
Dec 12, 2012·Virology·David M KnipeThomas M Kristie
Mar 8, 2013·Future Microbiology·Abhik Saha, Erle S Robertson
May 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Günter RaddatzFrank Lyko
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network

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Citations

Jan 30, 2016·Genome Medicine·Naoko Hattori, Toshikazu Ushijima
Aug 31, 2016·Nature Microbiology·Paul Farrell
Apr 20, 2016·Frontiers in Microbiology·Shaoni BhattacharjeeAbhik Saha
Nov 9, 2016·Frontiers in Microbiology·Hem C JhaErle S Robertson
Nov 26, 2016·Biomolecules·Shatadru Ghosh RoyAbhik Saha
Feb 11, 2016·Pathogens·Hem Chandra JhaErle S Robertson
Feb 13, 2017·Oral Diseases·J T GuidryR S Scott
Aug 5, 2018·Journal of Cellular Physiology·Sadegh FattahiHaleh Akhavan-Niaki
Aug 21, 2018·Annual Review of Pathology·Paul J Farrell
Apr 12, 2019·Journal of Virology·Abhik Saha, Erle S Robertson
Mar 29, 2019·Clinical Epigenetics·Zeina NehmeGeorges Herbein
Apr 20, 2017·Journal of Oncology·Shyam Singh, Hem Chandra Jha
Jun 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Merrin Man Long LeongMaria Li Lung
Dec 5, 2018·Reviews in Medical Virology·Javad CharostadEbrahim Faghihloo
Jun 3, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lucia MundoStefano Lazzi
Nov 1, 2020·Viruses·Lyla J Stanland, Micah A Luftig
Aug 8, 2021·International Journal of Molecular Sciences·Valeria PietropaoloUgo Moens

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