PMID: 11335110May 4, 2001Paper

Epigenetic targeting in the mouse zygote marks DNA for later methylation: a mechanism for maternal effects in development

Mechanisms of Development
B PickardJ Walter

Abstract

The transgenic sequences in the mouse line TKZ751 are demethylated on a DBA/2 inbred strain background but become highly methylated at postimplantation stages in offspring of a cross with a BALB/c female. In the reciprocal cross the transgene remains demethylated suggesting that imprinted BALB/c methylation modifiers or egg cytoplasmic factors are responsible for this striking maternal effect on de novo methylation. Reciprocal pronuclear transplantation experiments were carried out to distinguish between these mechanisms. The results indicate that a maternally-derived oocyte cytoplasmic factor from BALB/c marks the TKZ751 sequences at fertilization; this mark and postzygotic BALB/c modifiers are both required for de novo methylation of the target sequences at postimplantation stages. Using genetic linkage analyses we mapped the maternal effect to a locus on chromosome 17. Moreover, seven postzygotic modifier loci were identified that increase the postimplantation level of methylation. Analysis of interactions between the maternal and the postzygotic loci shows that both are needed for de novo methylation in the offspring. The combined experiments thus reveal a novel epigenetic marking process at fertilization which targets DNA ...Continue Reading

References

Dec 1, 1992·Mutation Research·S D Perreault
May 15, 1995·Genes & Development·J R ChailletP Leder
Jan 1, 1993·Methods in Enzymology·J A Lawitts, J D Biggers
Aug 1, 1995·Genome Research·W J PavanS M Tilghman
Sep 1, 1997·Molecular and Cellular Biology·K Weichman, J R Chaillet
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·E U Selker
May 13, 1999·Nature Genetics·J A JeddelohE J Richards
Feb 17, 2000·Nature·W MayerT Haaf
May 10, 2000·Current Biology : CB·J OswaldJ Walter
Mar 17, 2001·Nature Reviews. Genetics·W Reik, J Walter

❮ Previous
Next ❯

Citations

Jul 20, 2002·Trends in Genetics : TIG·Vardhman K RakyanEmma Whitelaw
Mar 3, 2004·Reproductive Biomedicine Online·Ri-Cheng ChianSeang-Lin Tan
Aug 8, 2009·Human Reproduction·Cheng-Guang LiangKeith E Latham
Feb 27, 2003·Biology of Reproduction·Gabriela Gebrin CezarKenneth J Eilertsen
Nov 13, 2004·Biology of Reproduction·Zhiming HanKeith E Latham
Dec 17, 2008·Biology of Reproduction·Yong ChengKeith E Latham
Sep 27, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wolf ReikWendy Dean
Sep 12, 2008·Biological Reviews of the Cambridge Philosophical Society·Bernard Crespi
Jul 28, 2005·Journal of Biomedicine & Biotechnology·Jonathan D Wren, Harold R Garner
Apr 7, 2007·Pediatric Research·Wayne S CutfieldIan M Morison
Jan 5, 2011·Nutrition Reviews·Abalo Chango, Latifa Abdennebi-Najar
Jul 31, 2003·Reproduction in Domestic Animals = Zuchthygiene·S Hiendleder, E Wolf
May 15, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·S Jill JamesMario A Cleves
Aug 1, 2006·Neuroscience·K M KramerB S Cushing
Nov 1, 2005·Journal of Theoretical Biology·Jon F Wilkins
Mar 16, 2005·Developmental Biology·Fátima SantosWendy Dean
Jan 8, 2008·Molecular and Cellular Endocrinology·Déborah Bourc'his, Charlotte Proudhon
Oct 26, 2012·Laboratory Animals·Wanyong PangAxel Kornerup Hansen
Sep 22, 2001·Electrophoresis·W Reik, W Dean
Nov 12, 2005·Genesis : the Journal of Genetics and Development·Amanda R DuselisPaul B Vrana
Oct 4, 2017·Reproductive Biology and Endocrinology : RB&E·Sara DarbandiMohammad Mehdi Akhondi
Aug 19, 2004·Journal of Cell Science·Olga F SarmentoScott A Coonrod
May 15, 2021·Biological Reviews of the Cambridge Philosophical Society·Kat Bebbington, Ton G G Groothuis
Aug 11, 2001·Science·A C Ferguson-Smith, M A Surani
Aug 11, 2001·Science·W ReikJ Walter
Jan 30, 2004·Reproductive Biomedicine Online·Zsolt Peter Nagy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.