Nov 9, 2017

Epigenetic Transitions and Knotted Solitons in Stretched Chromatin

Scientific Reports
D MichielettoD Marenduzzo

Abstract

The spreading and regulation of epigenetic marks on chromosomes is crucial to establish and maintain cellular identity. Nonetheless, the dynamic mechanism leading to the establishment and maintenance of tissue-specific, epigenetic pattern is still poorly understood. In this work we propose, and investigate in silico, a possible experimental strategy to illuminate the interplay between 3D chromatin structure and epigenetic dynamics. We consider a set-up where a reconstituted chromatin fibre is stretched at its two ends (e.g., by laser tweezers), while epigenetic enzymes (writers) and chromatin-binding proteins (readers) are flooded into the system. We show that, by tuning the stretching force and the binding affinity of the readers for chromatin, the fibre undergoes a sharp transition between a stretched, epigenetically disordered, state and a crumpled, epigenetically coherent, one. We further investigate the case in which a knot is tied along the chromatin fibre, and find that the knotted segment enhances local epigenetic order, giving rise to "epigenetic solitons" which travel and diffuse along chromatin. Our results point to an intriguing coupling between 3D chromatin topology and epigenetic dynamics, which may be investigate...Continue Reading

Mentioned in this Paper

In Silico
Enzymes, antithrombotic
Three-dimensional
Regulation of Biological Process
Chromosomes, Human
Study of Epigenetics
Binding Protein
Enzymes for Treatment of Wounds and Ulcers
Knot (Abnormality)
Chromosomes

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