Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?

Translational Psychiatry
Jakob A KaminskiIMAGEN Consortium

Abstract

Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Co...Continue Reading

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Citations

Jul 1, 2020·Molecular Psychiatry·Lea Mascarell MaričićUNKNOWN IMAGEN consortium
Dec 18, 2019·Clinical Epigenetics·Larissa HaertleAndré Mégarbané
May 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Nicholas JuddTorkel Klingberg
Jul 25, 2021·International Journal of Environmental Research and Public Health·Kyung-Shin LeeYun-Chul Hong

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