Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants

Nature Communications
Sebastian AlvaradoMoshe Szyf

Abstract

Complex quantitative traits, like size and behaviour, are a pervasive feature of natural populations. Quantitative trait variation is the product of both genetic and environmental factors, yet little is known about the mechanisms through which their interaction generates this variation. Epigenetic processes, such as DNA methylation, can mediate gene-by-environment interactions during development to generate discrete phenotypic variation. We therefore investigated the developmental role of DNA methylation in generating continuous size variation of workers in an ant colony, a key trait associated with division of labour. Here we show that, in the carpenter ant Camponotus floridanus, global (genome-wide) DNA methylation indirectly regulates quantitative methylation of the conserved cell-signalling gene Epidermal growth factor receptor to generate continuous size variation of workers. DNA methylation can therefore generate quantitative variation in a complex trait by quantitatively regulating the transcription of a gene. This mechanism, alongside genetic variation, may determine the phenotypic possibilities of loci for generating quantitative trait variation in natural populations.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S S SmithE M Newman
Nov 7, 1980·Science·A Razin, A D Riggs
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·R JüttermannR Jaenisch
Mar 19, 1999·Molecular and Cellular Biology·L BrodayM Costa
Mar 22, 2002·Nature·Lars M SteinmetzRonald W Davis
Mar 22, 2003·Experimental Cell Research·Robert N JorissenAntony W Burgess
Jul 16, 2003·Molecular and Cellular Biology·Robert A Waterland, Randy L Jirtle
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·William O H HughesJacobus J Boomsma
Aug 28, 2003·Developmental Biology·H F Nijhout
Jun 1, 1953·The Quarterly Review of Biology·E O WILSON
Feb 14, 2004·Human Molecular Genetics·Martin Farrall
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
May 6, 2005·Nature·Juergen Kroymann, Thomas Mitchell-Olds
Apr 21, 2006·Experimental Cell Research·Mohsen KarimiTomas J Ekström
May 12, 2007·Evolution; International Journal of Organic Evolution·Derek A Roff
May 16, 1902·Science·W M Wheeler
Jul 17, 1981·Science·D E Wheeler, H F Nijhout
Oct 30, 2007·Epigenetics : Official Journal of the DNA Methylation Society·Maja Klug, Michael Rehli
Jan 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert J SchmitzRichard M Amasino
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farah D LubinJ David Sweatt
May 5, 2009·Genome Research·Jonathan Flint, Trudy F C Mackay
Jun 27, 2009·PLoS Genetics·Frank JohannesVincent Colot
Apr 17, 2010·Science·Assaf ZemachDaniel Zilberman
Apr 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Suhua FengSteven E Jacobsen
May 19, 2010·Nature Reviews. Genetics·Evan E EichlerJoseph H Nadeau
Jun 22, 2010·Nature Genetics·Jian YangPeter M Visscher
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Diane C Wiernasz, Blaine J Cole
Aug 28, 2010·Science·Roberto BonasioJürgen Liebig
Nov 13, 2010·Nucleic Acids Research·Monica C Munoz-TorresChristine G Elsik
Apr 26, 2011·Nature·Masaki Kamakura
Jun 18, 2011·Nature Reviews. Genetics·Étienne DanchinSimon Blanchet
Nov 11, 2011·The Journal of Experimental Biology·Navdeep S MuttiGro V Amdam
Jan 10, 2012·Evolution; International Journal of Organic Evolution·Matthew V Rockman
Jan 10, 2012·Science·Rajendhran RajakumarEhab Abouheif
Mar 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sylvain ForetRyszard Maleszka
Mar 21, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Sabrina L Samudio-Ruiz, Laurie G Hudson
Sep 18, 2012·Nature Neuroscience·Brian R HerbAndrew P Feinberg
Dec 6, 2012·Genome Research·Daniel F SimolaShelley L Berger

❮ Previous
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Citations

Jul 21, 2016·Current Opinion in Insect Science·Miguel CoronaDiana E Wheeler
Dec 23, 2015·Current Opinion in Insect Science·Jennifer A Brisson, Gregory K Davis
Feb 3, 2016·Marine Genomics·David C H Metzger, Patricia M Schulte
Mar 2, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Melvin M BonillaDavid W Zeh
Jul 21, 2016·Current Opinion in Insect Science·J M Jandt, D M Gordon
Jul 12, 2016·Behavioral Ecology and Sociobiology·Deborah M Gordon
May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Teiya Kijimoto, Armin P Moczek
Aug 31, 2013·PLoS Genetics·Robert J KloseNeil Brockdorff
Apr 7, 2016·Annual Review of Neuroscience·D A Friedman, D M Gordon
Aug 20, 2016·Frontiers in Plant Science·Dohyup KimAllison K Hansen
Nov 2, 2016·Journal of Evolutionary Biology·R PlanquéJ B van den Berg
Sep 16, 2016·Proceedings. Biological Sciences·Jacob J Herman, Sonia E Sultan
Oct 31, 2015·PloS One·Sebastian G AlvaradoRussell D Fernald
Dec 31, 2015·PloS One·Kapa LenkovRussell D Fernald
Dec 25, 2016·Arthropod Structure & Development·Yiwen WangBernard Moussian
Jun 9, 2017·PLoS Genetics·Guillaume RivierePascal Favrel
Sep 21, 2017·PloS One·Arnaud UngaroAndré Gilles
Oct 27, 2017·Annual Review of Entomology·Bill D WillsAndrew V Suarez
Nov 28, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Richard GawneH Frederik Nijhout
Jan 28, 2017·Behavioral Ecology : Official Journal of the International Society for Behavioral Ecology·Gavin M LeightonAnna Dornhaus
Sep 14, 2018·Frontiers in Plant Science·Brennan H BakerSonia E Sultan
May 24, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elizabeth A TibbettsJames Dale
Sep 1, 2017·Genome Biology and Evolution·Karl M GlastadBrendan G Hunt
May 21, 2019·PLoS Genetics·Michael R WarnerTimothy A Linksvayer
Jul 3, 2017·The Journal of Chemical Physics·Fernanda B NunesSergio d'Almeida Sanchez
Jul 25, 2018·Scientific Reports·Carlos Antônio Mendes Cardoso-JúniorVincent Dietemann
Oct 27, 2020·Integrative and Comparative Biology·Sebastian G Alvarado
Jan 24, 2021·BMC Genomics·María I PozoHans Jacquemyn
Nov 19, 2020·Genesis : the Journal of Genetics and Development·Nhan Duc NguyenHajime Watanabe
May 11, 2021·Frontiers in Behavioral Neuroscience·Rebecca R Westwick, Clare C Rittschof

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