Epigenetics and depression: current challenges and new therapeutic options

Current Opinion in Psychiatry
Marc SchroederHelge Frieling

Abstract

Epigenetics comprises heritable but concurrent variable modifications of genomic DNA defining gene expression. The aim of this publication is to review the field of epigenetics in depression. Within this scope, we outline potential therapeutic options evolving in this young field of psychiatric research. Recently published papers show that epigenetic mechanisms like histone modifications and DNA methylation affect diverse pathways leading to depression-like behaviors in animal models. Adverse alterations of gene expression profiles, including glucocorticoid receptor or brain-derived neurotrophic factor, were shown to be inducible by early life stress and reversible by epigenetic drugs. Postmortem studies revealed epigenetic changes in the frontal cortex of depressed suicide victims. There exists profound evidence for histone deacetylase inhibitors to be a novel line of effective antidepressants via counteracting previously acquired adverse epigenetic marks. Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding of early life stress in depression. The current research regarding epigenetic pharmaceuticals is promising and deserves further attention in depression ...Continue Reading

References

Aug 11, 2001·Science·T Jenuwein, C D Allis
May 28, 2004·Nature·Gerda EggerPeter A Jones
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Oct 28, 2004·Biochemical Society Transactions·C B YooP A Jones
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ian C G WeaverMoshe Szyf
Sep 2, 2006·Biological Psychiatry·Frederick A SchroederSchahram Akbarian
Oct 6, 2006·Experimental Cell Research·Bernd LenzDominikus Bönsch
Dec 22, 2006·Journal of Psychiatric Research·Helge FrielingStefan Bleich
Jun 2, 2007·The American Journal of Psychiatry·Marshal FolsteinWendy W Qiu
Sep 28, 2007·The American Journal of Psychiatry·Thomas HillemacherStefan Bleich
Oct 15, 2008·Annual Review of Pharmacology and Toxicology·Moshe Szyf
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Jan 20, 2009·Biological Psychiatry·Tania L RothJ David Sweatt
Feb 24, 2009·Nature Neuroscience·Patrick O McGowanMichael J Meaney
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Herbert E CovingtonEric J Nestler
Nov 10, 2009·Nature Neuroscience·Chris MurgatroydDietmar Spengler
Nov 18, 2009·Molecular Pharmacology·Dennis R GraysonRajiv P Sharma
Jan 1, 2010·Depression and Anxiety·Michael Rutter
Feb 6, 2010·Journal of Hematology & Oncology·Jiahuai TanDelong Liu
Mar 27, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Chris MurgatroydDietmar Spengler

❮ Previous
Next ❯

Citations

Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Renaud MassartLaurence Lanfumey
May 18, 2013·BMC Medicine·Uzoezi OzomaroCharles B Nemeroff
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Florian Duclot, Mohamed Kabbaj
Oct 30, 2013·Disease Markers·Firoza MamdaniMarquis P Vawter
Oct 22, 2014·Translational Psychiatry·K G SchrautD L Van den Hove
Jul 3, 2015·Brain Sciences·Joan Y Holgate, Selena E Bartlett
May 24, 2011·Pharmacological Reports : PR·Wanda Baer-DubowskaMichał Cichocki
Mar 1, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Antonio Preti
Jun 16, 2014·Biological Psychiatry·Emma L DempsterThalia C Eley
Dec 17, 2015·Annual Review of Clinical Psychology·Philip A FisherBrianna C Delker
Mar 27, 2015·Neural Plasticity·Lisa DoanJing Wang
Jun 9, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Oliver G BoschThomas C Wetter
Mar 7, 2012·Chronobiology International·Sylvia FreyChristian Cajochen
Jul 21, 2015·Chinese Medicine·Lin-Lin JingXue-Gang Sun
Jan 22, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hee-Ju KangJin-Sang Yoon
Sep 3, 2013·Journal of Affective Disorders·Hee-Ju KangJin-Sang Yoon
Jul 12, 2014·Journal of Affective Disorders·Bernardo Dell'OssoA Carlo Altamura
Feb 5, 2015·Neurobiology of Aging·Hee-Ju KangJin-Sang Yoon
Mar 4, 2015·Biomarkers in Medicine·Mike C JentschRobert A Schoevers
May 11, 2012·The International Journal of Neuropsychopharmacology·Cristiana CruceanuGustavo Turecki
May 9, 2014·Journal of Neural Transmission·Katharina DomschkeBernhard T Baune
Jun 15, 2016·Translational Psychiatry·K MalkiM G Tosto
Aug 25, 2016·BioMed Research International·Elizabeth E HullKathryn J Leyva
Oct 16, 2014·Journal of Psychopharmacology·Roger M Lane
Feb 24, 2017·Journal of Cellular Biochemistry·Amir TajbakhshAmir Avan
May 27, 2017·Biology Open·Aijaz Ahmad NaikIshan K Patro
Feb 20, 2019·Cell and Tissue Research·Muris HumoIpek Yalcin
Mar 23, 2012·Transplantation·Jennifer A McCaughanAlexander P Maxwell
Jun 9, 2017·Reviews in the Neurosciences·Ivan ZaletelNela Puškaš
Oct 29, 2015·Psychiatry Investigation·Hee-Ju KangJin-Sang Yoon
Aug 11, 2018·Current Psychiatry Reports·Andrea Bulbena-CabreM Mercedes Perez-Rodriguez
Nov 30, 2018·Neuroscience and Biobehavioral Reviews·Eline J KraaijenvangerMarco P M Boks
Feb 13, 2021·Neurochemical Research·Amir Sasan Bayani ErshadiAhmad Reza Dehpour
Apr 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel

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