Epigenetics and Epi-miRNAs: Potential markers/therapeutics in leukemia

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Fatemeh MemariNosratollah Zarghami

Abstract

Epigenetic variations can play remarkable roles in different normal and abnormal situations. Such variations have been shown to have a direct role in the pathogenesis of various diseases either through inhibition of tumor suppressor genes or increasing the expression of oncogenes. Enzymes involving in epigenetic machinery are the main actors in tuning the epigenetic-based controls on gene expressions. Aberrant expression of these enzymes can trigger a big chaos in the cellular gene expression networks and finally lead to cancer progression. This situation has been shown in different types of leukemia, where high or low levels of an epigenetic enzyme are partly or highly responsible for involvement or progression of a disease. DNA hypermethylation, different histone modifications, and aberrant miRNA expressions are three main epigenetic variations, which have been shown to play a role in leukemia progression. Epigenetic based treatments now are considered as novel and effective therapies in order to decrease the abnormal epigenetic modifications in patient cells. Different epigenetic-based approaches have been developed and tested to inhibit or reverse the unusual expression of epigenetic agents in leukemia. The reciprocal behav...Continue Reading

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Citations

Nov 28, 2018·Journal of Cellular Physiology·Behnaz TaheriNosratollah Zarghami
Jul 10, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Cristiana Libardi Miranda FurtadoClaudia Pessoa
May 21, 2019·Biomarker Insights·Kah Keng WongTina M Green
Dec 12, 2020·Critical Reviews in Oncology/hematology·Hussein SabitManel Esteller
Mar 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bashdar Mahmud HussenSoudeh Ghafouri-Fard
Apr 4, 2021·Biomedicines·Na-Hyun LeeJeongeun Hyun
Apr 3, 2021·Seminars in Cancer Biology·Jae Eun Lee, Mi-Young Kim
Jun 3, 2021·International Journal of Molecular Sciences·Katarzyna GębarowskaMonika Lejman

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