Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle

Frontiers in Immunology
Charles AramaOgobara K Doumbo

Abstract

A better understanding of stable changes in regulation of gene expression that result from epigenetic events is of great relevance in the development of strategies to prevent and treat infectious diseases. Histone modification and DNA methylation are key epigenetic mechanisms that can be regarded as marks, which ensure an accurate transmission of the chromatin states and gene expression profiles over generations of cells. There is an increasing list of these modifications, and the complexity of their action is just beginning to be understood. It is clear that the epigenetic landscape plays a fundamental role in most biological processes that involve the manipulation and expression of DNA. Although the molecular mechanism of gene regulation is relatively well understood, the hierarchical order of events and dependencies that lead to protection against infection remain largely unknown. In this review, we propose that host epigenetics is an essential, though relatively under studied, factor in the protection or susceptibility to malaria.

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Citations

Oct 15, 2019·Immunological Reviews·Claire LoiseauDenise L Doolan
Jul 12, 2020·Scandinavian Journal of Immunology·Marita Troye-BlombergAnn-Kristin Östlund Farrants
Jan 30, 2019·Frontiers in Cellular and Infection Microbiology·Monica Ararat-SarriaHernando Curtidor
Oct 14, 2020·Antimicrobial Agents and Chemotherapy·Utsav SenAshish Gupta
Jul 17, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Aline Marrara PradoFernanda Janku Cabral
Oct 30, 2021·PLoS Neglected Tropical Diseases·Desiré Casares-MarfilMarialbert Acosta-Herrera

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Methods Mentioned

BETA
genetic modifications
acetylation
histone acetylation

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