Epigenetics and Peripheral Artery Disease

Current Atherosclerosis Reports
Jonathan GolledgeSmriti Murali Krishna

Abstract

The term epigenetics is usually used to describe inheritable changes in gene function which do not involve changes in the DNA sequence. These typically include non-coding RNAs, DNA methylation and histone modifications. Smoking and older age are recognised risk factors for peripheral artery diseases, such as occlusive lower limb artery disease and abdominal aortic aneurysm, and have been implicated in promoting epigenetic changes. This brief review describes studies that have associated epigenetic factors with peripheral artery diseases and investigations which have examined the effect of epigenetic modifications on the outcome of peripheral artery diseases in mouse models. Investigations have largely focused on microRNAs and have identified a number of circulating microRNAs associated with human peripheral artery diseases. Upregulating or antagonising a number of microRNAs has also been reported to limit aortic aneurysm development and hind limb ischemia in mouse models. The importance of DNA methylation and histone modifications in peripheral artery disease has been relatively little studied. Whether circulating microRNAs can be used to assist identification of patients with peripheral artery diseases and be modified in order...Continue Reading

References

Nov 26, 1997·Lancet·J Golledge
Sep 16, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jonathan GolledgePaul Norman
May 25, 2007·Connective Tissue Research·Paul E NormanJonathan Golledge
Jan 6, 2009·Journal of Cellular and Molecular Medicine·Coen van SolingenAnton Jan van Zonneveld
Jul 23, 2009·Current Opinion in Cardiology·Jonathan Golledge, Paul E Norman
Mar 30, 2010·Atherosclerosis·Smriti M KrishnaJonathan Golledge
May 21, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jonathan Golledge, Paul E Norman
Oct 5, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tianrun LiWei Zhang
May 21, 2011·Atherosclerosis·Jonathan Golledge, Paul E Norman
Aug 23, 2011·Cardiovascular Research·Coen van SolingenAnton Jan van Zonneveld
Sep 10, 2011·Circulation Research·Reinier A BoonStefanie Dimmeler
Nov 26, 2011·Circulation Research·Denis R MerkMichael P Fischbein
Jan 25, 2012·The Journal of Clinical Investigation·Lars MaegdefesselPhilip S Tsao
Feb 24, 2012·Science Translational Medicine·Lars MaegdefesselPhilip S Tsao
Jun 14, 2012·The Journal of Biological Chemistry·Ke-Jie YinY Eugene Chen
Jun 19, 2012·BMC Medical Genomics·Matthew C PahlHelena Kuivaniemi
Mar 13, 2013·Current Opinion in Cardiology·Jonathan Golledge, Helena Kuivaniemi
May 30, 2013·Current Vascular Pharmacology·Matti AdamPhilip S Tsao
Jun 12, 2013·Journal of Vascular Surgery·Bernice Lai Yee Cheuk, Stephen Wing Keung Cheng
Oct 17, 2013·Circulation. Cardiovascular Genetics·Philip W StatherMatthew J Bown
Jan 25, 2014·Scientific Reports·Yoko Endo-TakahashiYukihiko Aramaki
May 7, 2014·VASA. Zeitschrift für Gefässkrankheiten·Wanda KloosErwin Blessing
May 9, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Chan Woo KimHanjoong Jo
Aug 12, 2014·The American Journal of Cardiology·Mahyar KhaleghiIftikhar J Kullo
Sep 10, 2014·Circulation Research·Anna ZampetakiManuel Mayr
Nov 2, 2014·Nature Communications·Lars MaegdefesselPhilip S Tsao
Feb 12, 2015·Clinical Science·Smriti Murali KrishnaJonathan Golledge
Mar 31, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Seema DangwalDiethelm Tschoepe
Apr 29, 2015·Clinical Biochemistry·Wenwen ZhangChangjian Liu
May 7, 2015·Journal of Cellular and Molecular Medicine·Zhiyong LeiJoost P G Sluijter
May 21, 2015·International Journal of Molecular Sciences·Evan J RyerGerard Tromp
May 21, 2015·International Journal of Molecular Sciences·Rafaelle SpearFlorence Pinet
May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge

❮ Previous
Next ❯

Citations

Jul 4, 2016·Journal of Tissue Viability·Shaurya JhambUsman H Malabu
Sep 20, 2016·Journal of Vascular Surgery·Jonathan GolledgeRonald L Dalman
Nov 3, 2017·Current Cardiology Reports·Nathan Belkin, Scott M Damrauer
Jan 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Smriti Murali KrishnaJonathan Golledge
Jul 7, 2019·Journal of Internal Medicine·J GolledgeA Wanhainen
Nov 18, 2018·Nature Reviews. Cardiology·Jonathan Golledge
Oct 19, 2019·International Journal of Molecular Sciences·Smriti Murali Krishna
Sep 12, 2020·British Journal of Pharmacology·Jonathan GolledgeYutang Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Related Papers

Current Heart Failure Reports
Irene Mateo LeachRudolf A de Boer
World Journal of Gastroenterology : WJG
Changwon KangMi Young Kim
© 2022 Meta ULC. All rights reserved