Epigenetics, development, and the kidney

Journal of the American Society of Nephrology : JASN
Gregory R Dressler

Abstract

How cells partition the genome into active and inactive genes and how that information is established and propagated during embryonic development are fundamental to maintaining the normal differentiated state. The molecular mechanisms of epigenetic action and cellular memory are increasingly amenable to study primarily as a result of the rapid progress in the area of chromatin biology. Methylation of DNA and modification of histones are critical epigenetic marks that establish active and silent chromatin domains. During development of the kidney, DNA-binding factors such as Pax2/8, which are essential for the intermediate mesoderm and the renal epithelial lineage, could provide the locus and tissue specificity for histone methylation and chromatin remodeling and thus establish a kidney-specific fate. The role of epigenetic modifications in development and disease is under intense investigation and has already affected our view of cancer and aging.

References

Jan 1, 1988·Annual Review of Genetics·D Solter
Mar 7, 1996·Nature·K H CampbellI Wilmut
Feb 13, 1999·Nature Genetics·P A Jones, P W Laird
May 14, 1999·Current Opinion in Genetics & Development·H H Ng, A Bird
Sep 24, 1999·Developmental Biology·T J Carroll, P D Vize
Aug 11, 2001·Science·T Jenuwein, C D Allis
Nov 9, 2001·The Journal of Biological Chemistry·Yi CaiGregory R Dressler
Feb 23, 2002·Science·Steven A Jacobs, Sepideh Khorasanizadeh
Jun 7, 2002·Genes & Development·Deneen M WellikMario R Capecchi
Sep 28, 2002·Nature·Helena Santos-RosaTony Kouzarides
Oct 11, 2002·Nature·Sooryanarayana VaramballyArul M Chinnaiyan
Nov 19, 2002·Genes & Development·Maxime BouchardMeinrad Busslinger
Nov 28, 2002·Molecular Cell·Thomas A MilneJay L Hess
Dec 20, 2002·Developmental Biology·Richard G James, Thomas M Schultheiss
Feb 18, 2003·Molecular and Cellular Biology·Eun Ah ChoGregory R Dressler
Apr 3, 2003·Nature Reviews. Molecular Cell Biology·Siavash K Kurdistani, Michael Grunstein
Apr 5, 2003·Annual Review of Biochemistry·Laura N RuscheJasper Rine
Oct 25, 2003·Science·Isaac A MankeMichael B Yaffe
Jan 6, 2004·Genetics·Pamela E Bennett-BakerDavid T Burke
Jan 13, 2006·Trends in Biochemical Sciences·Robert J Klose, Adrian P Bird
Mar 31, 2006·Current Topics in Microbiology and Immunology·T Chen, E Li
May 2, 2006·Current Opinion in Genetics & Development·Cory M Valley, Huntington F Willard

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Citations

Dec 22, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert WoronieckiKatalin Susztak
Dec 6, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lyndsay A Harshman, Patrick D Brophy
Mar 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adam M ZawadaGunnar H Heine
Jan 21, 2010·Current Opinion in Pediatrics·V Matti Vehaskari
Dec 14, 2012·American Journal of Physiology. Renal Physiology·Hang YuanRama Natarajan
Dec 31, 2009·Development·Carolina RosselotCathy Mendelsohn
Jun 27, 2009·Journal of the American Society of Nephrology : JASN·Masayo NaitoKarol Bomsztyk
Oct 25, 2011·Journal of the American Society of Nephrology : JASN·Marpadga A Reddy, Rama Natarajan
May 19, 2010·Biomarkers in Medicine·Hirendra Nath Banerjee, Mukesh Verma
Sep 26, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ihor V Yosypiv
Jan 8, 2014·Nursing Research and Practice·Samantha M BomottiSharon L R Kardia
May 13, 2014·Cell and Tissue Research·Wibke Bechtel-Walz, Tobias B Huber
Apr 22, 2015·International Journal of Molecular Medicine·Xiangcheng XiaoPingping Yu
Sep 10, 2013·Seminars in Nephrology·Marpadga A ReddyRama Natarajan
Sep 2, 2011·Kidney International·John Cijiang HeRavi Iyengar
Nov 4, 2010·Seminars in Nephrology·Davoud Mohtat, Katalin Susztak
Jul 21, 2009·Seminars in Nephrology·Carolyn L Abitbol, Julie R Ingelfinger
Dec 1, 2015·Frontiers in Physiology·Ben KeXiangdong Fang
Aug 11, 2011·Journal of Cellular Physiology·Gavino FaaVassilios Fanos
Oct 3, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marco PiluduGavino Faa
Oct 14, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Clara GerosaNicoletta Iacovidou
Oct 14, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Daniela FanniGavino Faa
Aug 26, 2016·Clinical and Experimental Pharmacology & Physiology·Imari MimuraMasaomi Nangaku
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Michael Zeisberg, Eric G Neilson
Apr 10, 2010·Journal of the American Society of Nephrology : JASN·Paola Romagnani
Sep 15, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gavino FaaVassilios Fanos
Jul 10, 2014·Physiological Genomics·Lei YanSamir S El-Dahr
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yulu GuXiaoyan Zhang
Nov 22, 2018·Disease Models & Mechanisms·Carmen Hurtado Del PozoNuria Montserrat
Sep 9, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Silvio MaringhiniFrancesco Leone
Feb 23, 2018·Frontiers in Cell and Developmental Biology·Salvador Cazorla-Vázquez, Felix B Engel
Mar 20, 2010·Current Opinion in Pediatrics

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