Epigenetics in endometrial carcinogenesis - part 2: histone modifications, chromatin remodeling and noncoding RNAs

Epigenomics
Carla BartoschCarmen Jerónimo

Abstract

Carcinogenesis is a multistep multifactorial process that involves the accumulation of genetic and epigenetic alterations. In the past two decades, there has been an exponential growth of knowledge establishing the importance of epigenetic changes in cancer. Our work focused on reviewing the main role of epigenetics in the pathogenesis of endometrial carcinoma, highlighting the reported results concerning each epigenetic mechanistic layer. In a previous review, we assessed DNA methylation alterations. The present review examines the contribution of histone modifications, chromatin remodeling and noncoding RNA alterations for endometrial carcinogenesis.

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Citations

Aug 12, 2018·International Journal of Molecular Sciences·Tom Van NyenFrédéric Amant
Apr 4, 2021·International Journal of Molecular Sciences·Roberto PiergentiliFederica Perelli
Aug 7, 2021·Journal of Cosmetic Dermatology·Jianbiao HeYan Jia
Aug 28, 2021·Healthcare·Anna Franca CavaliereFabrizio Signore

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Methods Mentioned

BETA
histone acetylation
histone deacetylation

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