Epigenetics in Parkinson's Disease

Advances in Experimental Medicine and Biology
Maria Angeliki S Pavlou, Tiago F Outeiro

Abstract

Parkinson's disease (PD) is a highly complex neurodegenerative disorder with a multifactorial origin. Although several cellular mechanisms and genes have been implicated in the onset and progression of the disease, the precise molecular underpinnings of the disease remain unclear. In this context, epigenetic modulation of gene expression by environmental factors is emerging as an important mechanism in PD and in other neurodegenerative disorders. Thus, epigenetic mechanisms, such as DNA methylation, histone modifications and altered microRNA expression, have been under intense investigation due to their possible involvement in PD. Epigenetic modulation is responsible for inducing differential gene expression, a phenomenon which is essential throughout life in order to regulate multiple cellular responses such as development, cellular fate commitment and adaptation to the environment. Disturbances of a balanced gene expression can, therefore, have detrimental effects. Environmental factors can challenge the establishment and maintenance of epigenetic modifications and could thereby fill the gap in our further understanding of origin and/or progression of neurodegenerative diseases. In this chapter, we focus on the role of epigen...Continue Reading

Citations

Mar 16, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Adrienne Henderson-SmithPaula Desplats
Sep 13, 2019·Epigenetics : Official Journal of the DNA Methylation Society·María E Pérez-MartínezVicente Tordera
Sep 19, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Surbhi SharmaMartin R Schiller
May 13, 2020·Epigenomics·Cassandra ThompsonJulien Rossignol
Aug 23, 2020·Antioxidants·Laura Bordoni, Rosita Gabbianelli
Nov 15, 2018·Frontiers in Nutrition·Ines BanjariViduranga Y Waisundara
Dec 12, 2020·Computational and Structural Biotechnology Journal·Changliang WangGarry Wong
Mar 4, 2021·Ageing Research Reviews·Elena G PasyukovaAlexander M Vaiserman
May 14, 2021·Frontiers in Genetics·Adrienne R HendersonTravis Dunckley
Jul 29, 2021·Neuropathology and Applied Neurobiology·Megha MurthyConceição Bettencourt
Dec 12, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Guangxia YuHuangyuan Li

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