Epigenetics: It's Getting Old. Past Meets Future in Paleoepigenetics

Trends in Ecology & Evolution
David GokhmanLiran Carmel

Abstract

Recent years have witnessed the rise of ancient DNA (aDNA) technology, allowing comparative genomics to be carried out at unprecedented time resolution. While it is relatively straightforward to use aDNA to identify recent genomic changes, it is much less clear how to utilize it to study changes in epigenetic regulation. Here we review recent works demonstrating that highly degraded aDNA still contains sufficient information to allow reconstruction of epigenetic signals, including DNA methylation and nucleosome positioning maps. We discuss challenges arising from the tissue specificity of epigenetics, and show how some of them might in fact turn into advantages. Finally, we introduce a method to infer methylation states in tissues that do not tend to be preserved over time.

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Citations

May 18, 2016·Trends in Ecology & Evolution·Marleen M P Cobben, Kees van Oers
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Mar 7, 2020·Nature Communications·David GokhmanLiran Carmel
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Apr 23, 2021·ELife·Carly V WeissDavid Gokhman

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