PMID: 11921194Mar 29, 2002Paper

Epigenetics of breast cancer: polycyclic aromatic hydrocarbons as risk factors

Environmental and Molecular Mutagenesis
B D JeffyDonato F Romagnolo

Abstract

In the absence of a causal relationship between the incidence of sporadic breast cancer and occurrence of mutations in breast cancer susceptibility genes, efforts directed to investigating the contribution of environmental xenobiotics in the etiology of sporadic mammary neoplasia are warranted. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants, which have been shown to induce DNA damage and disrupt cell cycle progression. In this report we discuss published data pointing to PAHs as a risk factor in carcinogenesis, and present findings generated in our laboratory suggesting that the mammary tumorigenicity of PAHs may be attributable, at least in part, to disruption of BRCA-1 expression by reactive PAH-metabolites. We report that benzo[a]pyrene (B[a]P), selected as a prototype PAH, disrupts BRCA-1 transcription in estrogen receptor (ER)-positive but not ER-negative breast cancer cells. The reduced potential for BRCA-1 expression in B[a]P-treated cells coincides with disruption of cell cycle kinetics and accumulation of p53. These effects are counteracted by the AhR-antagonist alpha-naphthoflavone (ANF), and in breast cancer cells expressing mutant p53 or the E6 human papilloma virus protein. We suggest that exposu...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J WeiB D Preston
May 1, 1991·Toxicology and Industrial Health·H A Hattemer-Frey, C C Travis
Aug 1, 1990·Environmental Health Perspectives·D W NebertA J Fornace
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·A E AustJ J McCormick
Oct 7, 1994·Science·P A FutrealY Miki
Mar 1, 1996·Nature Genetics·J T HoltR A Jensen
Dec 1, 1995·Toxicology Letters·S Safe, V Krishnan
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·J V RajanL A Chodosh
Jan 9, 1997·Oncogene·J R MarksJ D Iglehart
Apr 24, 1997·Nature·K W Kinzler, B Vogelstein
Jul 9, 1998·Molecular Carcinogenesis·D RomagnoloC A Afshari
May 7, 1999·Environmental Health Perspectives·R E ShackelfordR S Paules
Jun 8, 1999·Journal of the National Cancer Institute·J PetoM R Stratton
Oct 3, 1999·Molecular Carcinogenesis·B D JeffyD Romagnolo
Jul 8, 2000·The Journal of Biological Chemistry·T K MacLachlanW S El-Deiry
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C X Deng, S G Brodie
Sep 26, 2000·Molecular and Cellular Biology·P AriztiS W Lee
Feb 24, 2001·Neoplasia : an International Journal for Oncology Research·B D JeffyD F Romagnolo
Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N KazerouniN Rothman
May 8, 2001·Archives of Biochemistry and Biophysics·C A RichterM Hannink
Jul 5, 2005·Expert Opinion on Investigational Drugs·S SafeA McDougal

❮ Previous
Next ❯

Citations

Nov 30, 2012·Archives of Toxicology·Dimitrios AgasLuigi Marchetti
Oct 1, 2003·Trends in Endocrinology and Metabolism : TEM·Eliot M RosenItzhak D Goldberg
Mar 16, 2007·Journal of Exposure Science & Environmental Epidemiology·Judy S LaKindMichael N Bates
Jun 23, 2006·Archives of Environmental Health·Marilie D GammonRegina M Santella
Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G C ZografosN Panou
Jan 5, 2008·Environmental Health Perspectives·Rebecca HewittFrancis L Martin
Sep 16, 2006·Biological Chemistry·Jennifer J SchlezingerDavid H Sherr
Sep 30, 2005·Archives of Environmental Health·Harold I Zeliger
May 29, 2013·Biochimica Et Biophysica Acta·Shaolong FengXinming Wang
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Fariba SalehiKristan J Aronson
May 21, 2013·Frontiers in Biology·Feng C Zhou
Nov 3, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Domenico PalliLaura Ottini
Dec 3, 2014·Environmental Pollution·Maria Isabel Cerezo, Susana Agustí
Aug 29, 2013·BioMed Research International·M D Ronquillo-SánchezJ J Espinosa-Aguirre
Jun 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Olguín-ReyesJ J Espinosa-Aguirre
Oct 2, 2007·Toxicology and Applied Pharmacology·Bekim SadikovicDavid I Rodenhiser
Jun 16, 2017·Environmental Science and Pollution Research International·Courtney Large, Yudan Wei
Feb 14, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Hui-Chen WuMary Beth Terry
Sep 16, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tamara Musafia-JeknicWilliam M Baird
Aug 3, 2016·Iranian Journal of Cancer Prevention·Andrew GlushkovSvetlana Ragozhina
Sep 3, 2020·Environmental Science and Pollution Research International·Muhammad Yasir Abdur RehmanJabir Hussain Syed
Oct 28, 2020·Critical Reviews in Food Science and Nutrition·Peramaiyan RajendranSurapaneni Krishna Mohan
Aug 10, 2021·Environmental Science and Pollution Research International·Lina ZhouYinyan He
Aug 15, 2021·Environmental Pollution·Marius Nils MüllerEliete Zanardi-Lamardo
Sep 10, 2021·Annual Review of Pharmacology and Toxicology·Lucie LarigotXavier Coumoul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.