Epigenetics of metabolic syndrome

Physiological Genomics
Caryn Carson, Heather A Lawson

Abstract

The dramatic increase in global prevalence of metabolic disease is inexplicable when considering only environmental or only genetic factors, leading to the need to explore the possible roles of epigenetic factors. A great deal of progress has been made in this interdisciplinary field in recent years, with many studies investigating various aspects of the metabolic syndrome and its associated epigenetic changes. Rodent models of metabolic diseases have been particularly illuminating because of the ability to leverage tools such as genetic and environmental modifications. The current review summarizes recent breakthroughs regarding epigenetic markers in studies of obesity, Type II diabetes, and cardiovascular disease, the three major disorders associated with metabolic syndrome. We also discuss open questions and future directions for integrating genomic, epigenomic, and phenotypic big biodata toward understanding metabolic syndrome etiology.

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Citations

Jun 6, 2020·Journal of the Endocrine Society·Adeline DivouxSteven R Smith
Aug 19, 2020·Antioxidants & Redox Signaling·Stefano MasiSarah Costantino
Aug 15, 2019·Nutrients·Adam WróblewskiAgnieszka Śliwińska
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Jan 5, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Annalisa MarottaFrancesco Gianfagna
Jul 5, 2019·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Samuel HamiltonMichel Bernier
Feb 6, 2021·International Journal of Molecular Sciences·Alvaro CerdaRosario Dominguez Crespo Hirata
Jun 15, 2021·Nutrición hospitalaria·Luis Adolfo Santos-CalderónCelia Aradillas-García

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