Epigenetics of pain mediators

Current Opinion in Anaesthesiology
Daniel W Odell

Abstract

The field of epigenetics continues its influential rise as a means to better understand an organism's unique developmental identity over a lifespan. Whereas a genome is constant and unchanging, an epigenome is dynamic and alterable. Epigenetic changes are in response to innumerable internal and external influences including environmental changes such as diet, exercise, disease, toxins, and stress. Epigenetics is of particular interest in the medical research community both for the potential to cause disease and as a target for therapeutic interventions. This article provides a succinct explanation of the potential for epigenetics to influence the understanding of pain as well as a review of relevant research on the topic. Studies on epigenetics and pain remain largely preclinical and investigate the theoretical ability of epigenetics to alter the nociceptive pathways both in the periphery and centrally. Significant evidence now exists for the ability of epigenetics to modify broadly categorized pain types, including inflammatory, neuropathic, visceral, and cancer related. Both patients and providers recognize that novel medications for the treatment of both acute and chronic pain conditions are sorely needed. The understanding ...Continue Reading

References

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Citations

Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S M Géranton
Jan 22, 2020·Neural Regeneration Research·Feng-Jiao LiDong-Mei Wang
Feb 3, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vittoria Borgonetti, Nicoletta Galeotti
Jul 28, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Eunice López-Muñoz, Gabriel Enrique Mejía-Terrazas
Nov 27, 2021·Molecular Pain·Danzhi LuoJun Zhou

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Methods Mentioned

BETA
acetylation
histone acetylation

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