Epigenetics of the yeast galactose genetic switch.

Journal of Biosciences
Paike Jayadeva Bhat, Revathi S Iyer

Abstract

The transcriptional activation of enzymes involved in galactose utilization (GAL genes) in Saccharomyces cerevisiae is regulated by a complex interplay between three regulatory proteins encoded by GAL4 (transcriptional activator), GAL3 (signal transducer) and GAL80 (repressor). The relative concentrations of the signal transducer and the repressor are maintained by autoregulation. Cells disabled for autoregulation exhibit phenotypes distinctly different from that of the wild type cells, enabling us to explore the biological significance of autoregulation. The redundancy in signal transduction due to the presence of GAL1 (alternate signal transducer) also makes it a suitable model to understand the phenomenon of epigenetics. In this article we review some of the recent attempts made to understand the importance of epigenetics in the establishment of cellular and transcriptional memory.

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Citations

Jan 18, 2011·Eukaryotic Cell·Virginia Williams, Maurizio Del Poeta
Jul 9, 2011·The Biochemical Journal·Jin ZhaoNorbert Lehming
Feb 4, 2014·FEMS Microbiology Reviews·Michaela ConradJohan M Thevelein
Oct 21, 2014·Molecular BioSystems·Sarah R StockwellScott A Rifkin
Apr 30, 2017·Current Genetics·Emi Kunitake, Tetsuo Kobayashi
May 31, 2013·The Journal of Biological Chemistry·Paresh SharmaSanjay A Desai
Mar 13, 2018·Bioresource Technology·Yujia ZhaoChun Li

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