Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease

Clinical Epigenetics
Masahiro NakatochiMitsuhiro Yokota

Abstract

Development of cardiovascular disease (CVD), including coronary artery disease, arrhythmia, and ischemic stroke, depends on environmental and genetic factors. To investigate the epigenetic basis of myocardial infarction (MI), we performed an epigenome-wide association study for this condition in elderly Japanese subjects. A total of 192 case subjects with MI and 192 control subjects were recruited from hospital attendees and the general population, respectively. Genome-wide DNA methylation (DNAm) profiles for DNA isolated from whole blood were obtained by analysis with an Infinium HumanMethylation450 BeadChip. The relation of DNAm sites found to be significantly associated with MI to nearby single nucleotide polymorphisms (SNPs) previously shown to be associated with CVD was assessed in the control group. Three DNAm sites (cg06642177, cg07786668, cg17218495) showed genome-wide significant associations with MI (p = 4.33 × 10-8, 3.96 × 10-10, and 3.77 × 10-8, respectively). Two of these sites (cg07786668, cg17218495) still showed such associations after adjustment for classical risk factors of MI (p = 1.04 × 10-7and 6.60 × 10-8, respectively). The DNAm sites cg07786668 and cg17218495 are located inZFHX3(zinc finger homeobox 3) an...Continue Reading

References

Sep 7, 2002·Hypertension·Andreas BusjahnFlorian Lang
Dec 13, 2002·The New England Journal of Medicine·Yoshiji YamadaMitsuhiro Yokota
Feb 26, 2005·Human Molecular Genetics·Pedro P MedinaMontserrat Sanchez-Cespedes
Jan 20, 2009·Nature Genetics·Zachary A KaminskyArt Petronis
Feb 10, 2009·Nature Genetics·UNKNOWN Myocardial Infarction Genetics ConsortiumDavid Altshuler
Jul 15, 2009·Nature Genetics·Daniel F GudbjartssonKari Stefansson
Jul 15, 2009·Nature Genetics·Emelia J BenjaminJacqueline C M Witteman
Mar 12, 2010·Genome Research·Vardhman K RakyanTimothy D Spector
Mar 20, 2010·PloS One·Myungjin KimPeter W Laird
Apr 14, 2010·PloS One·Jingyu LiuVince D Calhoun
Apr 5, 2011·American Journal of Human Genetics·Lutz P BreitlingHermann Brenner
May 28, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Scott M LangevinKarl T Kelsey
Jul 12, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Fang Fang ZhangAlfredo Morabia
Jul 13, 2011·Nature Reviews. Genetics·Vardhman K RakyanStephan Beck
Oct 6, 2011·European Journal of Human Genetics : EJHG·Fumihiko TakeuchiNorihiro Kato
Sep 8, 2012·Genome Research·Alan P BoyleMichael Snyder
Dec 4, 2012·Nature Genetics·Panos DeloukasNilesh J Samani
Dec 4, 2012·Nucleic Acids Research·Paul FlicekStephen M J Searle
Jan 15, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Yi-an ChenRosanna Weksberg
Jun 12, 2013·Global Heart·Ralph B D'AgostinoSean Coady
Jul 3, 2013·Nature Reviews. Genetics·Jonathan Mill, Bastiaan T Heijmans
Nov 23, 2013·Stroke; a Journal of Cerebral Circulation·Martin DichgansUNKNOWN International Stroke Genetics Consortium
Feb 6, 2014·Genome Biology·Andrew E Jaffe, Rafael A Irizarry
Mar 19, 2014·Lancet·Katherine J DickNilesh J Samani
Jan 15, 2015·Circulation. Cardiovascular Genetics·Liliane PfeifferMelanie Waldenberger
Jul 15, 2015·Journal of the American College of Cardiology·Masafumi Kitakaze
Apr 4, 2016·International Journal of Cardiology·Taulant MukaOscar H Franco

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Citations

May 15, 2018·International Journal of Molecular Sciences·Carlos Manuel Zapata-Martín Del CampoVerónica Guarner-Lans
Jan 29, 2018·Current Atherosclerosis Reports·Sarah T AhmedSalim S Virani
May 23, 2019·Human Genetics·Minyoung Lee, Hyongbum Kim
May 31, 2019·Annals of the Rheumatic Diseases·Hilal Ince-AskanRadboud J E M Dolhain
May 31, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Anastasia Z KaleaJessica L Buxton
Jan 18, 2020·Briefings in Functional Genomics·Anu Radha SharmaPadmalatha S Rai
Jan 30, 2020·Natural Product Reports·Levi W EvansBradley S Ferguson
Dec 6, 2019·Circulation Research·Biqi WangHonghuang Lin
Aug 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Peng ZhangJi-Min Cao
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Melanie S HulshoffElisabeth M Zeisberg
Oct 28, 2019·Frontiers in Genetics·Carolina Soler-BotijaAntoni Bayés-Genís
Mar 27, 2020·Frontiers in Genetics·Yasmeen SalamehNady El Hajj
Sep 16, 2020·Clinical Epigenetics·Chang ShuKe Xu
Feb 3, 2021·International Journal of Molecular Sciences·Hyun-Jeong YangHojung Kang
Feb 28, 2020·Pharmacology & Therapeutics·Concetta SchianoClaudio Napoli
Apr 6, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Gloria C ChiJoel D Kaufman
Apr 11, 2021·Clinical Epigenetics·Guillermo Palou-MárquezRoberto Elosua
Jul 16, 2021·Frontiers in Cell and Developmental Biology·Hui XuYou-Shuo Liu
Aug 28, 2021·Biomedicines·Rosanna Capparelli, Domenico Iannelli
Sep 14, 2021·ELife·Jiahui SiUNKNOWN China Kadoorie Biobank Collaborative Group

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Clinical Trials Mentioned

NCT00262691

Software Mentioned

RegulomeDB
Body Map
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