Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS).

International Journal of Molecular Sciences
Ting XieS Visvikis-Siest

Abstract

Epigenome-Wide Association Studies (EWAS) are furthering our knowledge of epigenetic modifications involved in the regulation of lipids' metabolism. Furthermore, epigenetic patterns associated with lipid levels may play an important role in predicting the occurrence of cardiovascular events. To further investigate the relationship between methylation status and lipids, we performed an EWAS in 211 individuals from the STANISLAS Family study (SFS). Methylation at two CpG sites (PRKAG2; p = 1.39 × 10-8; KREMEN2; p = 5.75 × 10-9) were significantly associated with lipidomic profiles. Replication was sought in adipose tissue where one probe, cg08897188, was found to be nominally significant (KREMEN2; p = 0.0196). These results could provide new insight in the mechanisms underlying cardiovascular diseases and contribute to new therapeutic interventions.

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jun 1, 1997·European Journal of Biochemistry·D G Hardie, D Carling
Jun 5, 2002·Genome Research·W James KentDavid Haussler
Jan 28, 2005·The New England Journal of Medicine·Michael AradJ G Seidman
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Giancarlo V De FerrariRandall T Moon
Oct 17, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R SarzaniA Rappelli
Nov 10, 2009·Behavior Research Methods·Franz FaulAlbert-Georg Lang
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Feb 2, 2011·Nature Reviews. Cardiology·Benoit J ArsenaultJohn J P Kastelein
May 18, 2011·Circulation·Diane E HandyJoseph Loscalzo
Jul 13, 2011·Nature Reviews. Genetics·Vardhman K RakyanStephan Beck
Aug 16, 2011·Genomics·Marina BibikovaRichard Shen
Mar 28, 2012·Bioinformatics·Richard T BarfieldKaren N Conneely
May 30, 2012·Nature Reviews. Genetics·Peter A Jones
Jan 15, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Yi-an ChenRosanna Weksberg
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Jan 15, 2015·Circulation. Cardiovascular Genetics·Liliane PfeifferMelanie Waldenberger
Jun 29, 2016·Genome Biology·Koen F DekkersBastiaan T Heijmans
Nov 5, 2016·Progress in Lipid Research·Kim V E BraunOscar H Franco
Dec 3, 2016·Nucleic Acids Research·Jacqueline MacArthurHelen Parkinson
Feb 15, 2017·Clinical Epigenetics·Kim V E BraunAbbas Dehghan
May 13, 2017·Current Cardiovascular Risk Reports·Sergi Sayols-BaixerasStella W Aslibekyan
Jun 29, 2017·International Journal of Preventive Medicine·Shivananda B NayakAkash S Nayak
Nov 21, 2017·Nucleic Acids Research·Daniel R ZerbinoPaul Flicek

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Citations

Jun 5, 2020·Circulation Research·Christoph D RauYibin Wang
Dec 9, 2020·Psychiatric Genetics·Adrien LegrandBoris Chaumette
Sep 2, 2021·Current Atherosclerosis Reports·Alana C JonesDonna K Arnett

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Methods Mentioned

BETA
biopsies
methylation profiling
Genotyping
chip

Software Mentioned

Package CpGassoc R
R
SWAN
Illumina
lmerTest
Power
UCSC browser
minfi R package
GenomeStudio
R package minfi

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