Epigenome-wide association study in peripheral white blood cells involving insulin resistance

Scientific Reports
Ana ArpónJ Alfredo Martínez

Abstract

Insulin resistance (IR) is a hallmark of type 2 diabetes, metabolic syndrome and cardiometabolic risk. An epigenetic phenomena such as DNA methylation might be involved in the onset and development of systemic IR. The aim of this study was to explore the genetic DNA methylation levels in peripheral white blood cells with the objective of identifying epigenetic signatures associated with IR measured by the Homeostatic Model Assessment of IR (HOMA-IR) following an epigenome-wide association study approach. DNA methylation levels were assessed using Infinium Methylation Assay (Illumina), and were associated with HOMA-IR values of participants from the Methyl Epigenome Network Association (MENA) project, finding statistical associations for at least 798 CpGs. A stringent statistical analysis revealed that 478 of them showed a differential methylation pattern between individuals with HOMA-IR ≤ 3 and > 3. ROC curves of top four CpGs out of 478 allowed differentiating individuals between both groups (AUC≈0.88). This study demonstrated the association between DNA methylation in some specific CpGs and HOMA-IR values that will help to the understanding and in the development of new strategies for personalized approaches to predict and pr...Continue Reading

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Citations

May 2, 2019·Frontiers in Endocrinology·Andrea G Izquierdo, Ana B Crujeiras
Mar 28, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Mirian SamblasAlfredo Martínez
Oct 15, 2020·Journal of Viral Hepatitis·Shazia RafiqueMuhammad Idrees
Mar 21, 2021·Clinical Epigenetics·Chiara MocciaLorenzo Richiardi
Mar 22, 2021·Aging·Athina VidakiManfred Kayser
May 29, 2021·Frontiers in Endocrinology·Hannah MaudeInês Cebola
Jul 1, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Markus RohnerStefan R Bornstein
Jul 23, 2021·Frontiers in Endocrinology·Sara AndradeMariana P Monteiro
Aug 13, 2021·Advanced Science·Siyu WeiYongshuai Jiang
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Chang Liu, Yan V Sun

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Datasets Mentioned

BETA
GSE115278

Methods Mentioned

BETA
methylation profiling
chip

Software Mentioned

ChAMP package for R
UNAV
R
PREDIMED
Ingenuity Pathway Analysis ( IPA )
OBEKIT
GraphPad Prism
GEDYMET
STATA
RESMENA

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