Sep 6, 2014

Glycyrrhizic acid improves cognitive levels of aging mice by regulating T/B cell proliferation

David JuanAlfonso Valencia


Licorice, the root of Glycyrrhiza glabra L. (Leguminosae), is one of the oldest known medicinal herbs. Glycyrrhizic acid (GA), a triterpenoid saponin isolated from licorice, has a variety of pharmacological activities. Previous studies indicate that GA produces neuroprotection via the modulation of anti-apoptotic and pro-apoptotic factors, primarily through the ERK signaling pathway and the suppression of inflammatory cytokine induction. However, the mechanisms of these neuroprotective effects and the effects of neuroimmunomodulation on cognition are not fully elucidated. This study investigated the effects of GA in preventing age-related immune involution and cognitive disorders as well as the relationship between immune involution and cognition and the underlying molecular mechanisms. Twelve-month-old female C57BL/6 mice were injected with GA (5mg/kg i.v. once every other day) for 6 weeks. Then, we tested the behavioral effects of GA using the Morris water maze task to evaluate spatial learning and memory. Age-related learning and memory impairments were prevented by GA treatment. This effect was accompanied by improved cerebral blood flow. Transcriptome analysis of C57BL/6 mice blood by RNA-sequencing and KEGG pathway analys...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Metabolic Process, Cellular
Establishment and Maintenance of Localization
Histone antigen
Complex (molecular entity)
Transcription, Genetic
Enhanced S-Cone Syndrome

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.