Sep 6, 2014

Glycyrrhizic acid improves cognitive levels of aging mice by regulating T/B cell proliferation

bioRxiv
David JuanAlfonso Valencia

Abstract

Licorice, the root of Glycyrrhiza glabra L. (Leguminosae), is one of the oldest known medicinal herbs. Glycyrrhizic acid (GA), a triterpenoid saponin isolated from licorice, has a variety of pharmacological activities. Previous studies indicate that GA produces neuroprotection via the modulation of anti-apoptotic and pro-apoptotic factors, primarily through the ERK signaling pathway and the suppression of inflammatory cytokine induction. However, the mechanisms of these neuroprotective effects and the effects of neuroimmunomodulation on cognition are not fully elucidated. This study investigated the effects of GA in preventing age-related immune involution and cognitive disorders as well as the relationship between immune involution and cognition and the underlying molecular mechanisms. Twelve-month-old female C57BL/6 mice were injected with GA (5mg/kg i.v. once every other day) for 6 weeks. Then, we tested the behavioral effects of GA using the Morris water maze task to evaluate spatial learning and memory. Age-related learning and memory impairments were prevented by GA treatment. This effect was accompanied by improved cerebral blood flow. Transcriptome analysis of C57BL/6 mice blood by RNA-sequencing and KEGG pathway analys...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Establishment and Maintenance of Localization
Mbd2
Nucleosomes
Histone antigen
Genome
Complex (molecular entity)
Transcription, Genetic
Coinfection
Enhanced S-Cone Syndrome

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