Epigenomic Indicators of Age in African Americans

Hereditary Genetics : Current Research
Jennifer A SmithSharon L R Kardia

Abstract

Age is a well-established risk factor for chronic diseases. However, the cellular and molecular changes associated with aging processes that are related to chronic disease initiation and progression are not well-understood. Thus, there is an increased need to identify new markers of cellular and molecular changes that occur during aging processes. In this study, we use genome-wide DNA methylation from 26,428 CpG sites in 13,877 genes to investigate the relationship between age and epigenetic variation in the peripheral blood cells of 972 African American adults from the Genetic Epidemiology Network of Arteriopathy (GENOA) study (mean age=66.3 years, range=39-95). Age was significantly associated with 7,601 (28.8%) CpG sites after Bonferroni correction for α=0.05 (p<1.89×10(-6)). Due to the extraordinarily strong associations between age and many of the CpG sites (>7,000 sites with p-values ranging from 10(-6) to 10(-43)), we investigated how well the DNA methylation markers predict age. We found that 2,095 (7.9%) CpG sites were significant predictors of age after Bonferroni correction. The top five principal components of the 2,095 age-associated CpG sites accounted for 69.3% of the variability in these CpG sites, and they expl...Continue Reading

Citations

May 5, 2016·Briefings in Functional Genomics·Liyuan HanYonghan He
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Abdullah Al MamunMohamed M Abdel-Daim

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Methods Mentioned

BETA
Genotyping
chip

Software Mentioned

Illumina BeadStudio
R package lmmfit
GENOA
R
nlme

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