Epigenomic profiling of preterm infants reveals DNA methylation differences at sites associated with neural function

Translational Psychiatry
S SparrowJ P Boardman

Abstract

DNA methylation (DNAm) plays a determining role in neural cell fate and provides a molecular link between early-life stress and neuropsychiatric disease. Preterm birth is a profound environmental stressor that is closely associated with alterations in connectivity of neural systems and long-term neuropsychiatric impairment. The aims of this study were to examine the relationship between preterm birth and DNAm, and to investigate factors that contribute to variance in DNAm. DNA was collected from preterm infants (birth<33 weeks gestation) and healthy controls (birth>37 weeks), and a genome-wide analysis of DNAm was performed; diffusion magnetic resonance imaging (dMRI) data were acquired from the preterm group. The major fasciculi were segmented, and fractional anisotropy, mean diffusivity and tract shape were calculated. Principal components (PC) analysis was used to investigate the contribution of MRI features and clinical variables to variance in DNAm. Differential methylation was found within 25 gene bodies and 58 promoters of protein-coding genes in preterm infants compared with controls; 10 of these have neural functions. Differences detected in the array were validated with pyrosequencing. Ninety-five percent of the varia...Continue Reading

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Datasets Mentioned

BETA
GSE72120

Methods Mentioned

BETA
PMA
electrophoresis
Assay
PCA

Software Mentioned

GenomeStudio Analysis
DTIFIT
PNT
PyroMark Q24
Limma
RnBeads
Ensembl
PyroMark Assay Design

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