Epigenomic programming in early fetal brain development.

Epigenomics
Luolan LiMartin Hirst

Abstract

Aim: To provide a comprehensive understanding of gene regulatory networks in the developing human brain and a foundation for interpreting pathogenic deregulation. Materials & methods: We generated reference epigenomes and transcriptomes of dissected brain regions and primary neural progenitor cells (NPCs) derived from cortical and ganglionic eminence tissues of four normal human fetuses. Results: Integration of these data across developmental stages revealed a directional increase in active regulatory states, transcription factor activities and gene transcription with developmental stage. Consistent with differences in their biology, NPCs derived from cortical and ganglionic eminence regions contained common, region specific, and gestational week specific regulatory states. Conclusion: We provide a high-resolution regulatory network for NPCs from different brain regions as a comprehensive reference for future studies.

References

Jul 1, 1995·Cerebral Cortex·H SteinmetzL Jäncke
Sep 25, 1999·Cerebral Cortex·D AcamporaA Simeone
Dec 5, 2000·Pediatric Research·P Gressens
Dec 5, 2000·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·T E Kennedy
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·Q R LuP M Black
May 23, 2002·Human Molecular Genetics·Rosanna WeksbergJeremy Squire
Jun 4, 2002·Nature Reviews. Neuroscience·Bagirathy Nadarajah, John G Parnavelas
Jul 13, 2002·The Anatomical Record·Norbert Ulfig
Sep 11, 2002·Clinical Genetics·S M SinghR O'Reilly
Aug 20, 2003·Journal of Neurosurgery·Corinne BouvierDominique Figarella-Branger
Jun 29, 2004·Trends in Neurosciences·Arnold R Kriegstein, Stephen C Noctor
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
Jul 19, 2005·Molecular Biology Reports·Chad S Hunter, Simon J Rhodes
Jul 30, 2005·Australian Dental Journal·G C TownsendW Schwerdt
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Igor Jakovcevski, Nada Zecevic
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Götz, Wieland B Huttner
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Jordane MalaterreTheo Mantamadiotis
Apr 11, 2007·Trends in Cell Biology·Joaquim Egea, Rüdiger Klein
Apr 13, 2007·Development·Jeff CaiQ Richard Lu
May 15, 2008·BMC Developmental Biology·Christine E CampbellRichard M Gronostajski
Dec 6, 2008·Molecular Neurobiology·Sharon MasonLinda J Richards
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Feb 19, 2009·Development, Growth & Differentiation·Takeshi Shimizu, Masahiko Hibi
Feb 16, 2010·Nature·David V HansenArnold R Kriegstein
Feb 24, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Andrea E CavannaFrancesco Monaco
May 4, 2010·Nature Biotechnology·Cory Y McLeanGill Bejerano
Oct 15, 2010·Nature Biotechnology·Stephan Beck
Nov 3, 2010·Neuropsychology Review·Joan Stiles, Terry L Jernigan
Apr 13, 2011·PloS One·Brette D BlakelyClare L Parish
Oct 28, 2011·Nature·Hyo Jung KangNenad Sestan
Dec 31, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Danuta GaletzkaThomas Haaf
Feb 7, 2012·American Journal of Human Genetics·Shusuke NumataBarbara K Lipska
Nov 20, 2012·Nature Neuroscience·Luca TiberiPierre Vanderhaeghen
Jul 6, 2013·Science·Ryan ListerJoseph R Ecker

❮ Previous
Next ❯

Citations

Jun 3, 2021·International Journal of Molecular Sciences·Jae-Yeon Kim, Mercedes F Paredes

❮ Previous
Next ❯

Datasets Mentioned

BETA
EGAS00001003368

Methods Mentioned

BETA
immunoprecipitation
WGBS
ChIP-seq
RNA-seq
dissection
MeDIP-seq

Software Mentioned

DAVID
UCSC genome browser
SAMtools mpileup
BCFtools
Cytoscape
UCSC
FindER
GREAT
matlab
Homer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.