Epigoitrin, an Alkaloid From Isatis indigotica , Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro

Frontiers in Pharmacology
Zhuo LuoRong-Rong He

Abstract

Stress has been proven to modulate an individual's immune system through the release of pituitary and adrenal hormones such as the catecholamines, growth hormone, and glucocorticoids. These signal molecules can significantly alter the host immune system and make it susceptible to viral infection. In this study, we investigate whether epigoitrin, a natural alkaloid from Isatis indigotica, provides protection against influenza infection by reducing the host's susceptibility to influenza virus under stress and its underlying mechanism. To support it, the mouse restraint stress model and the corticosterone-induced stress model were employed. Our results demonstrated that epigoitrin significantly decreased the susceptibility of restraint mice to influenza virus, evidenced by lowered mortality, attenuated inflammation, and decreased viral replications in lungs. Further results revealed that epigoitrin reduced the protein expression of mitofusin-2 (MFN2), which elevated mitochondria antiviral signaling (MAVS) protein expression and subsequently increased the production of IFN-β and interferon inducible transmembrane 3 (IFITM3), thereby helping to fight viral infections. In conclusion, our study indicated that epigoitrin could reduce t...Continue Reading

References

Sep 6, 2001·Respiration Physiology·A P Konstantinos, J F Sheridan
Mar 2, 2005·Nature Reviews. Immunology·Ronald Glaser, Janice K Kiecolt-Glaser
Jun 3, 2009·Nature Reviews. Endocrinology·George P Chrousos
Aug 20, 2009·Science Signaling·Kai YasukawaTakumi Koshiba
Mar 16, 2011·Journal of Agricultural and Food Chemistry·Rong-Rong HeHiroshi Kurihara
May 21, 2011·Nature Reviews. Immunology·A Phillip WestSankar Ghosh
Oct 29, 2011·Biochemical and Biophysical Research Communications·Mingli FangShucheng Hua
Jul 31, 2013·The American Journal of Chinese Medicine·Wei Zhou, Xiao-Yan Zhang
Apr 26, 2014·Nature Reviews. Immunology·Akiko Iwasaki, Padmini S Pillai
Jan 24, 2015·Nature Reviews. Immunology·Finlay McNabAnne O'Garra
Jul 30, 2016·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Ping XiaoXiang Li
Mar 21, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Huan ChenRong-Rong He
Jan 13, 2018·Archives of Virology·Binod KumarMelvin Sanicas

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Citations

Jul 18, 2020·Medicinal Research Reviews·Zhi-Jun ZhangRong-Tao Li
Nov 17, 2020·Frontiers in Pharmacology·Shengyan XiYong'an Ye
Mar 5, 2021·Frontiers in Pharmacology·Mohammad Bagher MajnooniJavier Echeverría
Mar 30, 2021·The Journal of Pharmacy and Pharmacology·Qiong ChenHong Zhang
Apr 10, 2021·Drug Design, Development and Therapy·Huihui TiShumei Wang
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yaoyao ChangHaitao Xiao

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Methods Mentioned

BETA
Bronchoalveolar Lavage
enzyme-linked immunosorbent assay
Assay
transfection
nuclear translocation

Software Mentioned

image J
GraphPad Prism

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