Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity

PloS One
Maria A GuimarãesJosé R S A Leite

Abstract

Schistosomiasis is a disease caused by parasites of the genus Schistosoma, currently affecting more than 200 million people. Among the various species of this parasite that infect humans, S. mansoni is the most common. Pharmacological treatment is limited to the use of a single drug, praziquantel (PZQ), despite reports of parasite resistance and low efficacy. It is therefore necessary to investigate new potential schistosomicidal compounds. In this study, we tested the efficacy of epiisopilosine (EPIIS) in a murine model of schistosomiasis. A single dose of EPIIS (100 or 400 mg/kg) administered orally to mice infected with adult S. mansoni resulted in reduced worm burden and egg production. The treatment with the lower dose of EPIIS (100 mg/kg) significantly reduced total worm burden by 60.61% (P < 0.001), as well as decreasing hepatosplenomegaly and egg excretion. Scanning electron microscopy revealed morphological changes in the worm tegument after treatment. Despite good activity of EPIIS in adult S. mansoni, oral treatment with single dose of EPIIS 100 mg/kg had only moderate effects in mice infected with juvenile S. mansoni. In addition, we performed cytotoxicity and toxicological studies with EPIIS and found no in vitro c...Continue Reading

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Citations

Dec 19, 2018·Antimicrobial Agents and Chemotherapy·Rafael A GuerraJosué de Moraes
Jun 4, 2020·Parasites & Vectors·Rogério P XavierJosué de Moraes
Nov 7, 2019·Brazilian Journal of Biology = Revista Brasleira De Biologia·T J Matos-RochaF A Brayner Dos Santos
Jan 23, 2021·RSC Medicinal Chemistry·Godwin Akpeko DziwornuKelly Chibale
Aug 22, 2021·Chemistry & Biodiversity·Paulo U CarnaúbaJosué de Moraes
Oct 6, 2021·Chemistry & Biodiversity·Lara Soares Aleixo de CarvalhoAdemar Alves Da Silva Filho

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Methods Mentioned

BETA
scanning electron microscopy
biosensors

Software Mentioned

GraphPad Prism
pkCSM

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