PMID: 9533204Apr 9, 1998Paper

Epilepsy and disorders of cortical development in children with congenital cytomegalovirus infection

Revista de neurologia
A Pérez-JiménezB Dalla-Bernardina

Abstract

Neuroimaging and experimental studies have related cytomegalovirus (CMV) to certain neuronal migration disorders. To define the electroclinical picture of children with epilepsy associated with disorders of cortical development (DCD) and congenital CMV infection, we conducted a clinical, electroencephalographic and neuroradiological study of 10 children with this condition. Eighty per cent of them had dismorphic traits, or malformations outside CNS. All showed other neuroradiological signs (cerebral calcification, white matter damage, porencephaly). Six patients with bihemispheric DCD (agyria-pachigyria, 2; 'poligyria', 1; schizencephaly, 1; bilateral opercular DCD, 2) showed: Tetraparesis, severe or profound mental deficiency, early onset epilepsy (mean age at onset: 11 months) with spasms, tonic seizures, partial seizures, and multifocal paroxysms or unusual diffuse sharp Alfa-Beta EEG activity. One child developed Epilepsia Partialis Continua. Children with bilateral opercular DCD evolved to a continuous spike and wave (SW) electrical status during wakefulness and sleep, linked to a worsening of psychomotor derangement. Four patients with unilateral hemispheric DCD (pachigyric or 'poligyric') showed: Congenital hemiparesis, ...Continue Reading

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Related Papers

Journal of Perinatology : Official Journal of the California Perinatal Association
M S SchimmelY Schlesinger
Radiographics : a Review Publication of the Radiological Society of North America, Inc
A KapilivskyM M Horrow
Jornal de pediatria
L H Falleiros-Carvalho
© 2022 Meta ULC. All rights reserved