PMID: 9180080DOI: 10.1126/science.276.5319.1699Jun 13, 1997Paper
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
Science
K TanakaK Wada
Abstract
Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.
References
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T StorckW Stoffel
Nov 27, 1992·Science·J D ClementsG L Westbrook
Dec 3, 1992·Nature·G PinesB I Kanner
Aug 9, 1991·Science·M L RiseT N Seyfried
Mar 29, 1991·Brain Research·M B RobinsonJ Sinor
Oct 1, 1990·Journal of Neurochemistry·T K McIntoshR Simon
Sep 21, 1990·Cell·A P McMahon, A Bradley
May 19, 1989·Science·A I FadenR Vink
Jan 1, 1987·CRC Critical Reviews in Biochemistry·B I Kanner, S Schuldiner
Oct 1, 1988·Neuron·D W Choi
May 15, 1986·Neuroscience Letters·A M PalmerD M Bowen
Sep 1, 1994·Trends in Neurosciences·M Szatkowski, D Attwell
Jul 1, 1995·Annals of Neurology·J D RothsteinR W Kuncl
Nov 15, 1994·Genomics·M A KirschnerS G Amara
May 1, 1995·Neuron·J I WadicheM P Kavanaugh
May 11, 1995·Biochimica Et Biophysica Acta·Y MukainakaK Wada
Jun 15, 1995·Nature·W A FairmanS G Amara
Oct 1, 1993·Journal of Neurophysiology·T ManabeR A Nicoll
Nov 1, 1993·Journal of Neurophysiology·J S Isaacson, R A Nicoll
Sep 1, 1994·Neuron·J D RothsteinR W Kuncl
Aug 12, 1996·Neuroreport·K YamadaY Inoue
❮ Previous
Next ❯
Citations
Jan 16, 1999·Journal of Neuroscience Research·F Jursky, N Nelson
Jul 21, 2000·Hippocampus·F BernalN Mahy
Apr 24, 2001·Muscle & Nerve·E A Fon, R H Edwards
Aug 25, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D T Joo, B A Orser
Aug 25, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F Sakai, K Amaha
Mar 28, 2008·Neurotoxicity Research·Anna KirykWojciech Danysz
Treadmill pre-training suppresses the release of glutamate resulting from cerebral ischemia in rats.
Jun 11, 2010·Experimental Brain Research·Jie JiaQing-Chuan Guo
Apr 10, 2007·The Journal of Membrane Biology·Baruch I Kanner
Sep 1, 2004·Pflügers Archiv : European journal of physiology·Nicola J AllenDavid Attwell
Nov 19, 2013·Pflügers Archiv : European journal of physiology·Christof GrewerThomas Rauen
Nov 25, 2011·Brain Structure & Function·Seok HeoGert Lubec
Mar 5, 2011·Amino Acids·Gabriel GrasAnne-Cécile Rimaniol
Mar 7, 2013·Amino Acids·Koji Aoyama, Toshio Nakaki
Mar 10, 2010·Apoptosis : an International Journal on Programmed Cell Death·Yan Wang, Zheng-Hong Qin
Nov 27, 2010·Cellular and Molecular Neurobiology·Stefanie BetteJürgen Engele
Jan 19, 2012·Cellular and Molecular Neurobiology·Tina UngerJürgen Engele
Aug 1, 2012·Neurochemical Research·Silvia MangiaMauro Dinuzzo
Jan 31, 2013·Transgenic Research·Jiao DengZhiyi Zuo
Oct 18, 2005·Journal of Biomedical Science·Ellas K NanitsosVladimir J Balcar
Feb 6, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Julie FotheringhamSteven Jacobson
Mar 20, 2002·Current Neurology and Neuroscience Reports·C E ShawN Leigh
Mar 7, 2012·Biological Trace Element Research·Yu DengWanyu Feng
Jan 5, 2012·Neurotoxicity Research·Carlos J BaierMarta C Antonelli
Feb 23, 2013·Behavioural Brain Research·Pierre Lavenex, Pamela Banta Lavenex
Nov 13, 2003·European Journal of Pharmacology·Yoshikatsu Kanai, Matthias A Hediger
Nov 13, 2003·European Journal of Pharmacology·Tiziana MenniniGiuseppe Campiani
Feb 6, 2004·European Journal of Pharmacology·Yumiko SekiyaMasamichi Satoh
Mar 27, 2004·European Journal of Pharmacology·Victoria ArmstrongSanders A McDougall
Apr 23, 2013·European Journal of Pharmacology·Ilsoon SonZhiyi Zuo
Dec 4, 2003·Epilepsy Research·Carolina SamuelssonElisabeth Ronne-Engström
Nov 28, 2013·Experimental Neurology·Han-Rong WengDylan W Maixner
Jun 14, 2005·Trends in Molecular Medicine·Kohichi Tanaka
Apr 2, 2004·Neurobiology of Disease·Nicholas J Maragakis, Jeffrey D Rothstein
May 18, 2004·Neurochemistry International·Richard PietStéphane H R Oliet
Dec 26, 2012·Neurochemistry International·M B GibbonsK S Wilcox
Feb 5, 2013·Neurochemistry International·Jacqueline A HubbardDevin K Binder
Feb 7, 2013·Neurochemistry International·Susan C Buckingham, Stefanie Robel
Aug 27, 2013·Neuropharmacology·Jun YangFang Wang
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Brian S Meldrum, Michael A Rogawski
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Albee MessingTracy L Hagemann
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yong-Jing Gao, Ru-Rong Ji
Oct 3, 2003·Trends in Neurosciences·Harald Sontheimer
Dec 31, 2003·Trends in Neurosciences·Shyam D Rao, John H Weiss
Jun 16, 2005·Toxicology·Lidia StruzyńskaGrzegorz Sulkowski
May 30, 2001·Brain Research·J W AllenM Aschner
Oct 26, 1999·Brain Research·T WatanabeK Tanaka
May 12, 2001·European Journal of Pharmacology·T NakagawaM Satoh
Dec 16, 1998·European Journal of Pharmacology·J DunlopR Franco
Jan 5, 2000·European Journal of Pharmacology·F ShimadaN Saito
Jun 5, 2003·Experimental Neurology·Charles R BuckRobert J McKeon
❮ Previous
Next ❯
Related Concepts
Related Feeds
Brain Injury & Trauma
brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.
Related Papers
Proceedings of the National Academy of Sciences of the United States of America
J L ArrizaS G Amara
Neuron
J D RothsteinR W Kuncl
The European Journal of Neuroscience
K WataseK Tanaka