Epilepsy and Neurodevelopmental Comorbidities in Tuberous Sclerosis Complex: A Natural History Study.

Pediatric Neurology
Ajay GuptaTSC Natural History Database Consortium

Abstract

We studied the natural history, genotype influence, and inter-relationship of epilepsy and neuropsychiatric disorders in tuberous sclerosis complex. Patients were identified using the TSC Natural History Database, the largest repository of longitudinally studied patients enrolled by the TSC Clinics Consortium. A cohort of 1657 TSC Natural History Database patients was analyzed. Eighty-eight percent patients (91% TSC2 vs 82% TSC1; P = 0.002) had epilepsy; TSC2 was more frequent with epilepsy onset at age less than two years (TSC2 82% vs TSC1 54%; P < 0.001) and infantile spasms (TSC2 56% vs TSC1 27%; P < 0.001). Frequency of intellectual disability (intelligence quotient less than 70) was higher when epilepsy coexisted (P < 0.001), but was not impacted by genotype (P = 0.08). Severe intellectual disability (intelligence quotient less than 50) was associated with epilepsy onset at age less than two years (P = 0.007), but not with the epilepsy duration (P = 0.45). Autism was diagnosed in 23% and was associated with epilepsy (P < 0.001), particularly with epilepsy onset at age less than two years (P = 0.02) but not with genotype (P = 0.06). Attention-deficit/hyperactivity disorder (age greater than four years) was diagnosed in 18% ...Continue Reading

References

Feb 1, 1993·Journal of Intellectual Disability Research : JIDR·A Hunt
Jan 1, 1994·Developmental Medicine and Child Neurology·I C GillbergG Ahlsén
May 25, 2004·Archives of Disease in Childhood·F J K O'CallaghanJ P Osborne
Aug 12, 2006·Journal of Child Neurology·Virginia Wong
Jan 24, 2007·Epilepsia·Francesca CormackTorsten Baldeweg
Feb 3, 2007·European Child & Adolescent Psychiatry·Petrus J de VriesPatrick F Bolton
Feb 17, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kit Sing AuHope Northrup
Sep 25, 2007·Journal of Child Neurology·Evald SaemundsenVilhjalmur Rafnsson
Oct 16, 2007·Epilepsy & Behavior : E&B·David A MuzykewiczElizabeth A Thiele
Oct 7, 2009·Journal of Child Neurology·Elisa D'AgatiPaolo Curatolo
Jan 1, 2010·Epilepsia·Catherine J Chu-ShoreElizabeth A Thiele
Mar 9, 2010·Journal of Child Neurology·Paolo CuratoloRomina Moavero
Mar 23, 2011·Journal of Child Neurology·Anne T BergRoberto Tuchman
Apr 22, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sergiusz JóźwiakMaria Respondek-Liberska
Oct 30, 2013·Nature Neuroscience·Mauro Costa-Mattioli, Lisa M Monteggia
Nov 6, 2013·Neuropsychology·Loretta van ItersonPeter F de Jong
Jun 12, 2014·Epilepsia·Sanjeev V KothareOrrin Devinsky
Dec 24, 2014·Pediatric Neurology·Petrus J de VriesAnna Jansen
Jun 13, 2015·Lancet Neurology·Paolo CuratoloPetrus J de Vries
Jul 15, 2016·Pediatrics·Elin Næs BertelsenSøren Dalsgaard
Jan 18, 2018·Expert Review of Neurotherapeutics·Paolo CuratoloEleonora Aronica
Mar 15, 2019·Epilepsia Open·Rima NabboutUNKNOWN TOSCA Consortium and TOSCA Investigators
Sep 5, 2019·Pediatric Neurology·Sergiusz JozwiakKatarzyna Kotulska

❮ Previous
Next ❯

Citations

Jul 3, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Pia BernardoClaudia Santoro
Dec 8, 2020·Pediatric Neurology Briefs·Jamie K Capal
Mar 23, 2021·Acta Neurologica Scandinavica·Aglaia VignoliMaria Paola Canevini
May 2, 2021·American Journal of Human Genetics·UNKNOWN Epi25 Collaborative. Electronic address: jm4279@cumc.columbia.edu, UNKNOWN Epi25 Collaborative
Oct 6, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alissa M D'Gama, Annapurna Poduri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Seizure : the Journal of the British Epilepsy Association
Working group of the International Association of the Scientific Study of Intellectual Disability
European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
K KotulskaS Jóźwiak
Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Mary B ConnollyPaul Steinbok
Pediatrics International : Official Journal of the Japan Pediatric Society
Zeynep GokerRezzan Aydin
© 2021 Meta ULC. All rights reserved