PMID: 11343735May 10, 2001Paper

Epilepsy control with phenobarbital or phenytoin in rural south India: the Yelandur study

Lancet
K S ManiD K Subbakrishna

Abstract

Epilepsy is a controllable disorder if detected and treated early. For most families in rural areas of less developed countries, however, treatment can be delayed because of the inaccessibility of specialist neurological assessment facilities. We aimed to find a practical solution to rural epilepsy control by doing a non-randomised trial in south India. 135 patients with partial or generalised tonic-clonic seizures agreed to long-term treatment with phenobarbital (n=68), phenytoin (n=60), or both (n=7). Drugs were given once daily, and at the lowest effective dose, by trained primary-care physicians and health workers. All management was entirely clinical. The main outcome measure was absence of seizures of any type for at least 2 years (terminal remission). Analysis was by intention to treat. The proportion with terminal remission at each of 4 successive years of follow-up ranged from 58% to 66% for patients who were drug compliant and who had a lifetime total of 30 or fewer generalised tonic-clonic seizures. The corresponding range for patients who were not compliant and who had ever had more than 30 such seizures was 6-16%. Multivariate logistic regression analysis confirmed that strict drug compliance and early treatment we...Continue Reading

References

Dec 2, 1978·Lancet·M H Shokeir
Apr 1, 1990·Archives of Disease in Childhood·H Foley
Mar 25, 1989·BMJ : British Medical Journal·A E Watts
Mar 1, 1987·Epilepsia·E H Reynolds
Oct 11, 1984·The New England Journal of Medicine·R D ElwesE H Reynolds
Jun 28, 1997·Lancet
Sep 11, 1998·Seizure : the Journal of the British Epilepsy Association·K S ManiA K Reddy
Jun 8, 1999·Lancet·D K PalJ W Sander

❮ Previous
Next ❯

Citations

May 7, 2005·Indian Journal of Pediatrics·Vrajesh Udani
Dec 17, 2008·Indian Journal of Pediatrics·Tapas K BanerjeeShyamal K Das
May 21, 2009·Nature Reviews. Neurology·Kurupath Radhakrishnan
Feb 1, 2003·Epilepsia·M Gourie-DeviG Gururaj
Feb 1, 2003·Epilepsia·K S Mani, D K Subbakrishna
Feb 1, 2003·Epilepsia·J M K Murthy
Sep 11, 2008·Epilepsia·Andre Pascal KengneJean Claude Mbanya
Jun 3, 2008·Epilepsia·Adam StrzelczykGünter Krämer
Aug 11, 2010·Epilepsy Currents·Gretchen L Birbeck
Oct 15, 2010·Epilepsy Currents·Gretchen L Birbeck
Nov 20, 2004·BMJ : British Medical Journal·Rajendra Kale, Emilio Perucca
Oct 14, 2009·PLoS Medicine·Caroline K Mbuba, Charles R Newton
Sep 13, 2012·PloS One·Elisa BrunoGuy Farnarier
Jan 1, 2008·Annals of Indian Academy of Neurology·Chhaya ValviMadhuri Agarwal
Nov 10, 2011·Journal of Pediatric Neurosciences·Pradnya Gadgil, Vrajesh Udani
Sep 8, 2001·Lancet·I MatherS Ramaiah
Oct 5, 2013·Epilepsy & Behavior : E&B·Jeffrey BigelowMamta Singh
Jan 26, 2012·Current Opinion in Neurology·Dieter Schmidt, Matti Sillanpää
Jul 27, 2007·Epilepsia·Jagarlapudi M K MurthyMeena A Kanikannan
Dec 12, 2012·Epilepsia·Martin J Brodie, Patrick Kwan
Jun 7, 2005·Expert Opinion on Drug Safety·Nithya J GogtayNilima A Kshirsagar
Mar 25, 2014·Epilepsy & Behavior : E&B·Youssoufa MaigaLionel Carmant
Feb 12, 2011·Epilepsy & Behavior : E&B·Emanuele BartoliniJosemir W Sander
Feb 20, 2015·Annals of African Medicine·Emmanuel Olatunde SanyaKudirat Busari
Apr 1, 2005·Indian Journal of Pediatrics·Vrajesh Udani
May 31, 2021·Seizure : the Journal of the British Epilepsy Association·Ali A Asadi-PooyaNafiseh Mirzaei Damabi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.