PMID: 9422251Dec 1, 1995Paper

Epilepsy in early development: the lesson from surgery for early intractable seizures

Seminars in Pediatric Neurology
R Caplan

Abstract

This report examines the impact on development and the problems involved in assessing development in very young children with early-onset intractable seizures, particularly infantile spasms. A review of studies on medically and surgically treated children with infantile spasms underscores the relationship between seizure control and developmental outcome. About 50% of children with markedly intractable infantile spasms attained seizure control and significant improvement in the use of nonverbal communication, a developmental measure that has been used in other populations of developmentally delayed children. With the exception of duration of illness, clinical measures of age of onset of infantile spasms, type of surgery, and side of surgery did not appear to be related to the postoperative change in nonverbal communication. The neuropathology findings of surgically treated children with infantile spasms suggest that the underlying pathology occurs early in brain development. In conclusion, the cumulative effect of uncontrolled seizures and the underlying pathology might impact the early development of children with intractable infantile spasms.

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Citations

Dec 26, 2003·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Victoria A GardnerLorraine Chessell
Jul 4, 1998·The British Journal of Surgery·C J VaizeyR J Nicholls
Apr 12, 2001·Saudi Medical Journal·S J CranksonS A Al-Jaddan
Jan 17, 2003·Critical Care Medicine·Randall C Wetzel, R Cartland Burns
Oct 8, 1999·Journal of Pediatric Gastroenterology and Nutrition·V H HeemskerkE Heineman
Sep 21, 2000·Journal of Pediatric Gastroenterology and Nutrition·L V McFarlandS Guandalini
May 4, 2002·The Journal of Trauma·Julie A MargenthalerMartin S Keller
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Rogier C J de JongeReinoud J B J Gemke
Dec 16, 2004·Pediatric Emergency Care·Stephen B Freedman, Susan Fuchs
Jun 11, 2003·Annals of Surgery·Joseph J TepasCarla DiScala
Jul 11, 2009·The Journal of Trauma·Troy A MarkelKimberly E Applegate
Aug 15, 2009·The Journal of Trauma·Mikael PetrosyanHenri R Ford
Feb 24, 2001·Drugs·K De Beule, J Van Gestel
Sep 2, 2008·Neurosurgical Focus·Cristina Go, O Carter Snead
May 30, 2001·Brain & Development·O C Snead

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