Epilepsy surgery in tuberous sclerosis complex: emphasis on surgical candidate and neuropsychology

Epilepsia
Shuli LiangYajing Sun

Abstract

To discuss neuropsychological outcome and candidate of epilepsy surgery for tuberous sclerosis complex (TSC). To retrospectively analyze clinical data of 25 patients with TSC and epilepsy who underwent epilepsy surgery between 2001 and 2007. Seizure reduction was analyzed at 1-year (1FU), 2-year (2FU), and 5-year (5FU) follow-up visits after surgery, and outcomes of intelligence quotient (IQ) and quality of life (QOL) were evaluated at 2FU. Resective procedures included 14 tuber resections, 9 lobectomies, and 2 tuber resections and lobectomies. Corpus callosotomies (CCTs) were performed as the adjunctive approach in eight cases with low IQ and behavioral problems. The percentages of seizure-free cases were 72% at 1FU, 60% at 2FU, and 54.5% at 5FU, and the factors predicting seizure freedom included the course of seizures and ages of patients. Significant improvement was found in performance IQ in patients with preoperative low IQ or CCT. Significant improvement in mean QOL score was observed in all patients, especially patients with preoperative low IQ and CCT but postoperative seizure freedom. To be surgical candidates, patients with TSC and epilepsy should have identified epileptogenic tubers, and candidates should include pa...Continue Reading

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Citations

May 25, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ignacio Pascual-Castroviejo
Jun 3, 2011·Journal of Neurosurgery. Pediatrics·Donato PacioneJonathan Roth
Jan 1, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·I Pascual-CastroviejoC Morales Bastos
Sep 12, 2012·Pediatric Neurology·Shuli LiangShaohui Zhang
May 19, 2017·Journal of Neurology·Shuli LiangPing Ding
May 27, 2016·Nature Reviews. Disease Primers·Elizabeth P HenskeElizabeth A Thiele
Jan 23, 2020·Orphanet Journal of Rare Diseases·Johann Philipp ZöllnerAdam Strzelczyk
Sep 16, 2021·PharmacoEconomics Open·Siu Hing LoAndrew Lloyd

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