Epilepsy with auditory features: Long-term outcome and predictors of terminal remission

Epilepsia
Francesca BisulliPaolo Tinuper

Abstract

To assess the long-term outcome of epilepsy with auditory features (EAF) and to identify the clinical predictors for prognosis. The study involved consecutive EAF patients with a follow-up of ≥5 years. Terminal remission (TR) was defined as a period of ≥5 consecutive years of seizure freedom at the last follow-up. We used Kaplan-Meier estimate to calculate the cumulative time-dependent probability of conversion to TR. Log-rank test and multivariate Cox regression analyses were performed to study the association between time to TR and prognostic determinants. We included 123 EAF patients (male/female = 58/65) with a median follow-up of 11 years (1626.9 person-years). Most were sporadic cases (68.3%), whereas 31.7% reported a family history of epilepsy. At last assessment, 42 patients had achieved TR (34.1%). Of the remaining 81 cases with no TR (65.9%), 37% had been in remission for 1-4 years and 62.9% still had seizures within the past year. The cumulative rates of TR were 26.6%, 35.7%, and 51.6% at 10, 20, and 30 years from inclusion. On multivariate analysis, age at onset > 10 years (hazard ratio [HR] = 3.2, P = .028), auditory aura characterized by distortions only versus simple/complex hallucinations (HR = 2.9, P = .041), a...Continue Reading

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Nov 25, 2016·Neurology·Laura LicchettaPaolo Tinuper

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Citations

Nov 18, 2020·Clinical Psychology & Psychotherapy·Sarah ParryFilippo Varese
Jan 17, 2021·Seizure : the Journal of the British Epilepsy Association·F BisulliL Licchetta

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