PMID: 15247544Jul 13, 2004Paper

Epilepsy

Current Opinion in Neurology
Matthias J Koepp, John S Duncan

Abstract

The purpose of this review is to consider the current and potential role of neuroimaging from an epilepsy perspective, and to illustrate that by combining appropriate imaging techniques, neuroimaging can contribute greatly to elucidating the basic mechanisms of the various forms of epileptic disorders. New magnetic resonance imaging sequences (magnetization transfer imaging) and positron emission tomography ligands (serotonergic system) were biologically validated in large groups of patients with localization-related epilepsies. Investigations in genetically determined homogenous patient populations (PAX6, juvenile myoclonic epilepsy) have strengthened the link between genetic defects and neuropathological targets (anterior commissure, thalamus). Magnetic resonance spectroscopy and electroencephalogram-triggered functional magnetic resonance imaging provided converging evidence for a key role of the thalamus in the generation of generalized seizures. The role of functional magnetic resonance imaging in identifying eloquent areas of cortex and its relationship to structural lesions, in particular malformations of cortical development, has been further elucidated. Longitudinal magnetic resonance imaging studies reported progressi...Continue Reading

References

Jul 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·I SavicG Blomqvist
Feb 1, 2002·American Journal of Human Genetics·Laurent VillardWilliam B Dobyns
Feb 15, 2002·American Journal of Human Genetics·Xianhua PiaoChristopher A Walsh
Jul 24, 2002·Brain : a Journal of Neurology·L TassiR Spreafico
Sep 3, 2002·Annals of Neurology·Sofia H ErikssonGeoffrey J M Parker
Feb 25, 2003·Human Brain Mapping·P M MatthewsS Iversen
Feb 26, 2003·Neurology·I A MóroczG Liu
Feb 26, 2003·Annals of Neurology·Rebecca S N LiuJohn S Duncan
Feb 26, 2003·Annals of Neurology·Darren FuerstCraig Watson
Apr 12, 2003·Brain : a Journal of Neurology·W Van PaesschenA Maes
May 6, 2003·Annals of Neurology·Tejal N MitchellSanjay M Sisodiya
May 6, 2003·Annals of Neurology·Afraim Salek-HaddadiDavid R Fish
May 24, 2003·Seizure : the Journal of the British Epilepsy Association·Deborah K SokolBhuwan Garg
May 24, 2003·Brain : a Journal of Neurology·Alexander HammersJohn S Duncan
May 29, 2003·Neurology·F J Rugg-GunnJ S Duncan
Jun 5, 2003·Annals of Neurology·Jozsef JanszkyFriedrich G Woermann
Jul 26, 2003·NeuroImage·Thomas J GrabowskiRichard D Hichwa
Aug 7, 2003·Brain : a Journal of Neurology·A BernasconiD L Arnold
Aug 14, 2003·Seizure : the Journal of the British Epilepsy Association·Nozomi AkanumaColin D Binnie
Aug 26, 2003·Brain : a Journal of Neurology·Rod C ScottAlan Connelly

❮ Previous
Next ❯

Citations

Feb 17, 2007·Epilepsy Currents·Bruce Hermann, Michael Seidenberg
Aug 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·T M Salmenpera, J S Duncan
Feb 14, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ye-Hwa JunJung-Min Kim
Jun 21, 2006·Expert Review of Neurotherapeutics·Alberto VerrottiEmilio Franzoni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.