Epileptic encephalopathy with continuous spikes and waves during sleep in children with shunted hydrocephalus: a study of nine cases

Epilepsia
Roberto CaraballoNatalio Fejerman

Abstract

We present a series of nine patients with early-onset hydrocephalus who had seizures and continuous spikes and waves during slow sleep (CSWS) associated with neurocognitive and motor deterioration. Six boys and three girls aged 9-16 years (mean 11.3 years) were studied. [Correction added after online publication 12-Apr-2008: Number of girls and boys has been updated.] All patients underwent clinical examinations, electroencephalographic evaluations, neuroradiological imaging and neuropsychological assessment at first examination. Antiepileptic drugs (AEDs) were given in all cases and changed according to clinical and EEG evolution. Onset of epilepsy occurred from age 8 to 60 months (mean 19.6 months and median 14 months) with focal seizures with or without secondary generalized tonic-clonic seizures. Between ages 6 and 13 years (mean 10.4 years and median 8 years), hyperkinesia, aggressiveness, and poor socialization appeared in all nine cases. Reduced attention span, deterioration of language, and temporospatial disorientation were found in three of them. Negative myoclonus was found in two patients. The EEG showed CSWS. Response to change in treatment was good in all patients. None of the patients had relapses, seven of them ...Continue Reading

References

Jun 1, 1977·Electroencephalography and Clinical Neurophysiology·D F Ines, O N Markand
Oct 1, 1994·Pediatric Neurology·A M SopranoN Fejerman
May 1, 1995·Journal of Child Neurology·P Lerman, T Lerman-Sagie
Oct 1, 1996·Neurosurgery·J H Piatt, C V Carlson
Jul 3, 1998·Pediatric Neurology·J M PratsP Madoz
Jul 11, 1998·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·P VeggiottiG Lanzi
Jan 9, 1999·Developmental Medicine and Child Neurology·J KlepperN Sörensen
Feb 9, 1999·Journal of Neurosurgery·M BourgeoisJ Aicardi
Jun 11, 1999·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D L Keene, E C Ventureyra
Sep 21, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C A TassinariR Michelucci
Mar 30, 2001·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·J P MonteiroT Deonna
Apr 10, 2004·Journal of Child Neurology·Bruria Ben-ZeevUri Kramer
Sep 20, 2006·Epilepsia·Jerome Engel

❮ Previous
Next ❯

Citations

Aug 18, 2009·Epilepsia·Carlo A TassinariGuido Rubboli
May 15, 2012·Epilepsia·Iván Sánchez FernándezTobias Loddenkemper
Dec 3, 2014·Seizure : the Journal of the British Epilepsy Association·Roberto Horacio CaraballoErnesto Portuondo
Aug 21, 2013·Pediatric Neurology·Iván Sánchez FernándezTobias Loddenkemper
Jan 8, 2013·Epilepsy & Behavior : E&B·Vamsidhar ChavakulaTobias Loddenkemper
Apr 24, 2012·Pediatric Neurology·Iván Sánchez FernándezTobias Loddenkemper
Aug 22, 2015·Epilepsia·Iván Sánchez FernándezSolomon L Moshé
Aug 31, 2013·Epilepsy Research and Treatment·Iván Sánchez FernándezTobias Loddenkemper
Nov 7, 2012·Pediatric Neurology·Iván Sánchez FernándezSanjeev V Kothare
May 7, 2013·Seizure : the Journal of the British Epilepsy Association·Sebastian FortiniRoberto Horacio Caraballo
Dec 4, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A B Kozhokaru

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.