Epileptic seizures in subcortical vascular encephalopathy

Journal of the Neurological Sciences
A SchreinerM Hennerici

Abstract

Cerebrovascular disease is one of the most common causes of epilepsy in the elderly. Most of the studies published relate to cortical infarction, subarachnoid, and intracranial hemorrhage, whereas the incidence of epilepsy from subcortical ischemia, i.e. deep lacunar infarctions and diffuse white matter lesions, is obscure. Therefore, we prospectively examined 18 patients with the precisely defined diagnosis of subcortical vascular encephalopathy (SVE), who were admitted to our hospital due to epileptic seizures (group A), and compared them to a similarly selected group matched for age, sex, risk factors, and neurological deficits with an equivalent severity of SVE but without seizures (group B). Subcortical lacunar infarctions were significantly more frequent in group A than group B (15/18 versus 4/18, p < 0.001), whereas neither the extension, degree, distribution of periventricular white matter changes, nor the presence of internal hydrocephalus, focal or diffuse cortical atrophy showed any statistical significance. However, a temporal constant theta or delta EEG focus was present in 10/18 patients in group A but only in 1/18 patients from group B (p < 0.005). 10/18 patients developed epilepsy with further seizures during fo...Continue Reading

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Citations

Feb 22, 2008·Epilepsia·Bernd Pohlmann-Eden, Mark Newton
Jul 16, 2011·Epilepsia·Bernd Pohlmann-Eden
Feb 14, 2006·BMJ : British Medical Journal·Bernd Pohlmann-EdenPeter Camfield
Feb 9, 2013·PloS One·Sandra OkroglicMichael T Heneka
Aug 4, 2004·Drugs & Aging·José M Ferro, Francisco Pinto
Jul 1, 1997·Stroke; a Journal of Cerebral Circulation·A EckertW E Müller
Dec 12, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S Arroyo, G Kramer
May 6, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sara GaspariniUNKNOWN Epilepsy Study Group of the Italian Neurological Society
Jul 7, 2001·Stroke; a Journal of Cerebral Circulation·C SartiUNKNOWN Italian Longitudinal Study on Aging (ILSA)
Nov 16, 2017·Journal of Clinical Neurology·Hyun Kyung Kim

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