PMID: 3763042Aug 29, 1986Paper

Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium

Neuroscience Letters
H WaltherB Hamon

Abstract

Reduction of [Mg2+]o induced spontaneous epileptiform activity consisting of 40-100-ms bursts of population spikes in hippocampal slices. This activity disappeared from area CA1 when the connections to area CA3 were cut, but persisted in isolated minislices of area CA3. Spontaneous activity was also observed in the dentate gyrus, provided that the connections to the subiculum and entorhinal cortex (EC) were intact. In the parasubiculum and EC longer lasting epileptiform events were observed which resembled seizure-like behaviour. The epileptiform activity was completely suppressed by 2-aminophosphonovalerate (30 microM) suggesting that N-methyl-D-aspartate receptors for excitatory amino acid transmitters participate in the generation of this activity. These findings show that the EC possesses properties which permit the generation of seizure-like activity in contrast to the hippocampus where the activity resembled recurrent interictal events.

References

Dec 1, 1979·Journal of Neuroscience Methods·H L HaasM Vosmansky
Jan 1, 1971·Experimental Brain Research·P AndersenK K Skrede
Jul 11, 1957·The Journal of Physiology·B FRANKENHAEUSER, A L HODGKIN

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Citations

Jun 1, 1994·Hippocampus·U HeinemannC Zhang
Jan 15, 1999·Molecular Neurobiology·D SchmitzU Heinemann
Aug 12, 2009·Journal of Biological Physics·Eunji E KangBerj L Bardakjian
May 5, 1987·Brain Research·H S SwartzwelderW A Wilson
Jul 14, 1995·Brain Research. Developmental Brain Research·T GloveliU Heinemann
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·J D LambertU Heinemann
Jan 1, 1991·Progress in Neurobiology·E W LothmanJ L Stringer
Sep 1, 1988·Epilepsy Research·W A WilsonD V Lewis
Oct 1, 1991·Epilepsy Research·U HeinemannC L Zhang

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