Epileptiform and non-epileptiform paroxysmal activity from isolated cortex after functional hemispherectomy

Electroencephalography and Clinical Neurophysiology
R A WennbergJ G Villemure

Abstract

The relationship of acute complete cortical isolation to paroxysmal cerebral activity was examined in 16 patients with electrocorticography (ECOG) before and after functional hemispherectomy (FH). Burst-suppression activity appeared over isolated cortex in all cases, the severity of which could be increased by systemic administration of propofol or methohexital. Interictal epileptiform activity (EA) recorded from frontal or parietal-occipital cortex before FH invariably persisted after FH (11 cases). No EA was recorded before or after FH in 3 cases while in 2 cases EA appeared following FH which had not been present before FH. The intensity of burst-suppression activity was not related to the presence or absence of post-excision EA. In total, 30 disconnected cortices were recorded from; relative abundance of EA was increased in 10, unchanged in 17, and decreased in 3 cases. Unrelated to the induction of burst-suppression activity, cortical isolation may decrease the threshold for expression of interictal EA.

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Citations

Sep 19, 1998·Electroencephalography and Clinical Neurophysiology·R WennbergT Rasmussen
Nov 25, 2003·Seizure : the Journal of the British Epilepsy Association·Abraham Kuruvilla, Roland Flink
Feb 19, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R A Wennberg
Nov 15, 2000·Epilepsia·T H SchwartzR R Goodman
Jan 19, 2010·Epilepsy Research·M TripathiP Sarat Chandra
Jan 11, 2005·Surgical Neurology·Philip M ThomasWilliam T O'Connor
Nov 30, 2012·Culture, Medicine and Psychiatry·Andrew R HatalaMargaret Crossley
May 31, 2001·Epilepsia·R A Wennberg, L F Quesney
Apr 9, 2017·Journal of Computational Neuroscience·X Zhao, P A Robinson

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