Epileptiform discharge propagation: Analyzing spikes from the onset to the peak

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Mihai Dragos MălîiaSándor Beniczky

Abstract

To investigate how often discharge propagation occurs within the spikes recorded in patients evaluated for epilepsy surgery, and to assess its impact on the accuracy of source imaging. Data were analyzed from 50 consecutive patients who had presurgical workup. Discharge propagation was analyzed using sequential voltage-maps of the averaged spikes, and principal components analysis. When propagation was detected, sources were modeled both at onset and peak. Propagation occurred in half of the patients. The median time of propagation between onset and peak was 17 ms. In 60% of the cases with propagation (15/25 patients) this remained in the same sub-lobar area where onset occurred. The accuracy of source imaging in cases of propagating spikes was 67% when only analyzing onset or peak. This was lower as compared to cases without propagation (79%). Combining source imaging at onset and at peak increased the accuracy to 83% for the propagating spikes. Propagation occurs often in patients with focal epilepsy, evaluated for surgery. In 40% of the propagating cases, the source of onset and peak were in different sub-lobar regions. For optimal clinical utility, sources should be modeled both at onset and at peak epochs of the spikes.

Associated Clinical Trials

References

Jan 1, 1991·Brain Topography·J S Ebersole
Sep 1, 1986·Electroencephalography and Clinical Neurophysiology·M Scherg, D Von Cramon
Nov 1, 1995·Epilepsia·E RodinJ Thompson
May 1, 1995·Electroencephalography and Clinical Neurophysiology·R G EmersonM Forgione
Apr 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·G AlarconC E Polkey
Jul 13, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·I Merlet, J Gotman
Jul 30, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M SchergP Berg
Aug 22, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H J HuppertzR Kristeva-Feige
Jan 1, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Göran LantzChristoph M Michel
Apr 7, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Lei DingBin He
Oct 1, 2011·AJNR. American Journal of Neuroradiology·N TanakaS M Stufflebeam
Oct 7, 2011·Brain : a Journal of Neurology·Verena BrodbeckMargitta Seeck
Dec 17, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yunfeng LuBin He
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Helen R SabolekKevin J Staley
Aug 5, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Abbas SohrabpourBin He
Oct 7, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert B YaffeSridevi V Sarma

❮ Previous
Next ❯

Citations

May 12, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P SharmaS Beniczky
Feb 13, 2018·Current Opinion in Neurology·Pierre Mégevand, Margitta Seeck
Aug 3, 2019·Brain : a Journal of Neurology·Stefan RamppMichael Buchfelder
Apr 1, 2020·Expert Review of Medical Devices·Pierre Mégevand, Margitta Seeck

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.